001018545 001__ 1018545
001018545 005__ 20240116084325.0
001018545 0247_ $$2doi$$a10.1016/j.neulet.2023.137456
001018545 0247_ $$2ISSN$$a0304-3940
001018545 0247_ $$2ISSN$$a1872-7972
001018545 0247_ $$2datacite_doi$$a10.34734/FZJ-2023-04873
001018545 0247_ $$2pmid$$a37648059
001018545 0247_ $$2WOS$$aWOS:001069379900001
001018545 037__ $$aFZJ-2023-04873
001018545 082__ $$a610
001018545 1001_ $$00000-0002-4429-0367$$aKohle, Felix$$b0$$eCorresponding author
001018545 245__ $$a2,4-Dinitrophenol does not exert neuro-regenerative potential in experimental autoimmune neuritis
001018545 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2023
001018545 3367_ $$2DRIVER$$aarticle
001018545 3367_ $$2DataCite$$aOutput Types/Journal article
001018545 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1701182885_23345
001018545 3367_ $$2BibTeX$$aARTICLE
001018545 3367_ $$2ORCID$$aJOURNAL_ARTICLE
001018545 3367_ $$00$$2EndNote$$aJournal Article
001018545 520__ $$aObjective: We evaluated the potential neuro-regenerative effects of the mitochondrial uncoupler 2,4-Dinitrophenol in experimental autoimmune neuritis, an animal model for an acute autoimmune neuropathy.Methods: Experimental autoimmune neuritis was induced in Lewis rats. Different concentrations of 2,4-Dinitrophenol (1 mg/kg, 0.1 mg/kg and 0.01 mg/kg) were applied during the recovery phase of the neuritis (at days 18, 22 and 26) and compared to the vehicle. Any effects were assessed through functional, electrophysiological, and morphological analysis via electron microscopy of all groups at day 30. Additional immune-histochemical analysis of inflammation markers and remyelination of the sciatic nerves were performed for the dosage of 1 mg/kg and control.Results: No enhancement of functional or electrophysiological recovery was observed in all 2,4-Dinitrophenol-treated groups. Cellular inflammation markers of T cells (CD3+) were comparable to control, and an increase of macrophages (IbA1+) invasion in the sciatic nerves was observed. Treatment with 2,4-Dinitrophenol reduced axonal swelling in myelinated and unmyelinated fibers with an increased production of brain-derived neurotrophic factor.Conclusion: Our findings do not support the hypothesis that repurposing of the mitochondrial uncoupler 2,4-Dinitrophenol exerts functionally relevant neuro-regenerative effects in autoimmune neuritis.Keywords: Autoimmune neuropathy; Brain-derived neurotrophic factor; Drug repurposing; Guillain-Barré syndrome; Mitochondrial uncoupler; Neuroregeneration.
001018545 536__ $$0G:(DE-HGF)POF4-5251$$a5251 - Multilevel Brain Organization and Variability (POF4-525)$$cPOF4-525$$fPOF IV$$x0
001018545 588__ $$aDataset connected to CrossRef, Journals: juser.fz-juelich.de
001018545 7001_ $$0P:(DE-HGF)0$$aAckfeld, Robin$$b1
001018545 7001_ $$0P:(DE-HGF)0$$aKlein, Ines$$b2
001018545 7001_ $$0P:(DE-HGF)0$$aSvačina, Martin K. R.$$b3
001018545 7001_ $$aSchneider, Christian$$b4
001018545 7001_ $$0P:(DE-HGF)0$$avan Beers, Tim$$b5
001018545 7001_ $$0P:(DE-HGF)0$$aGrandoch, Andrea$$b6
001018545 7001_ $$0P:(DE-Juel1)131720$$aFink, Gereon R.$$b7
001018545 7001_ $$0P:(DE-HGF)0$$aLehmann, Helmar C.$$b8
001018545 7001_ $$0P:(DE-HGF)0$$aBarham, Mohammed$$b9
001018545 773__ $$0PERI:(DE-600)1498535-4$$a10.1016/j.neulet.2023.137456$$gVol. 814, p. 137456 -$$p137456 -$$tNeuroscience letters$$v814$$x0304-3940$$y2023
001018545 8564_ $$uhttps://juser.fz-juelich.de/record/1018545/files/PDF-12.pdf
001018545 8564_ $$uhttps://juser.fz-juelich.de/record/1018545/files/POST%20PRINT.pdf$$yOpenAccess
001018545 8564_ $$uhttps://juser.fz-juelich.de/record/1018545/files/POST%20PRINT.gif?subformat=icon$$xicon$$yOpenAccess
001018545 8564_ $$uhttps://juser.fz-juelich.de/record/1018545/files/POST%20PRINT.jpg?subformat=icon-1440$$xicon-1440$$yOpenAccess
001018545 8564_ $$uhttps://juser.fz-juelich.de/record/1018545/files/POST%20PRINT.jpg?subformat=icon-180$$xicon-180$$yOpenAccess
001018545 8564_ $$uhttps://juser.fz-juelich.de/record/1018545/files/POST%20PRINT.jpg?subformat=icon-640$$xicon-640$$yOpenAccess
001018545 8564_ $$uhttps://juser.fz-juelich.de/record/1018545/files/PDF-12.gif?subformat=icon$$xicon
001018545 8564_ $$uhttps://juser.fz-juelich.de/record/1018545/files/PDF-12.jpg?subformat=icon-1440$$xicon-1440
001018545 8564_ $$uhttps://juser.fz-juelich.de/record/1018545/files/PDF-12.jpg?subformat=icon-180$$xicon-180
001018545 8564_ $$uhttps://juser.fz-juelich.de/record/1018545/files/PDF-12.jpg?subformat=icon-640$$xicon-640
001018545 909CO $$ooai:juser.fz-juelich.de:1018545$$pdnbdelivery$$pdriver$$pVDB$$popen_access$$popenaire
001018545 9101_ $$0I:(DE-HGF)0$$60000-0002-4429-0367$$a UK Köln$$b0
001018545 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131720$$aForschungszentrum Jülich$$b7$$kFZJ
001018545 9131_ $$0G:(DE-HGF)POF4-525$$1G:(DE-HGF)POF4-520$$2G:(DE-HGF)POF4-500$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$9G:(DE-HGF)POF4-5251$$aDE-HGF$$bKey Technologies$$lNatural, Artificial and Cognitive Information Processing$$vDecoding Brain Organization and Dysfunction$$x0
001018545 9141_ $$y2023
001018545 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
001018545 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz$$d2023-10-21$$wger
001018545 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bNEUROSCI LETT : 2022$$d2023-10-21
001018545 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2023-10-21
001018545 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2023-10-21
001018545 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2023-10-21
001018545 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2023-10-21
001018545 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2023-10-21
001018545 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2023-10-21
001018545 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2023-10-21
001018545 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2023-10-21
001018545 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5$$d2023-10-21
001018545 920__ $$lyes
001018545 9201_ $$0I:(DE-Juel1)INM-3-20090406$$kINM-3$$lKognitive Neurowissenschaften$$x0
001018545 980__ $$ajournal
001018545 980__ $$aVDB
001018545 980__ $$aUNRESTRICTED
001018545 980__ $$aI:(DE-Juel1)INM-3-20090406
001018545 9801_ $$aFullTexts