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@ARTICLE{Kohle:1018545,
      author       = {Kohle, Felix and Ackfeld, Robin and Klein, Ines and
                      Svačina, Martin K. R. and Schneider, Christian and van
                      Beers, Tim and Grandoch, Andrea and Fink, Gereon R. and
                      Lehmann, Helmar C. and Barham, Mohammed},
      title        = {2,4-{D}initrophenol does not exert neuro-regenerative
                      potential in experimental autoimmune neuritis},
      journal      = {Neuroscience letters},
      volume       = {814},
      issn         = {0304-3940},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2023-04873},
      pages        = {137456 -},
      year         = {2023},
      abstract     = {Objective: We evaluated the potential neuro-regenerative
                      effects of the mitochondrial uncoupler 2,4-Dinitrophenol in
                      experimental autoimmune neuritis, an animal model for an
                      acute autoimmune neuropathy.Methods: Experimental autoimmune
                      neuritis was induced in Lewis rats. Different concentrations
                      of 2,4-Dinitrophenol (1 mg/kg, 0.1 mg/kg and 0.01 mg/kg)
                      were applied during the recovery phase of the neuritis (at
                      days 18, 22 and 26) and compared to the vehicle. Any effects
                      were assessed through functional, electrophysiological, and
                      morphological analysis via electron microscopy of all groups
                      at day 30. Additional immune-histochemical analysis of
                      inflammation markers and remyelination of the sciatic nerves
                      were performed for the dosage of 1 mg/kg and
                      control.Results: No enhancement of functional or
                      electrophysiological recovery was observed in all
                      2,4-Dinitrophenol-treated groups. Cellular inflammation
                      markers of T cells (CD3+) were comparable to control, and an
                      increase of macrophages (IbA1+) invasion in the sciatic
                      nerves was observed. Treatment with 2,4-Dinitrophenol
                      reduced axonal swelling in myelinated and unmyelinated
                      fibers with an increased production of brain-derived
                      neurotrophic factor.Conclusion: Our findings do not support
                      the hypothesis that repurposing of the mitochondrial
                      uncoupler 2,4-Dinitrophenol exerts functionally relevant
                      neuro-regenerative effects in autoimmune neuritis.Keywords:
                      Autoimmune neuropathy; Brain-derived neurotrophic factor;
                      Drug repurposing; Guillain-Barré syndrome; Mitochondrial
                      uncoupler; Neuroregeneration.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {37648059},
      UT           = {WOS:001069379900001},
      doi          = {10.1016/j.neulet.2023.137456},
      url          = {https://juser.fz-juelich.de/record/1018545},
}