Home > Publications database > 2,4-Dinitrophenol does not exert neuro-regenerative potential in experimental autoimmune neuritis > print

001     1018545
005     20240116084325.0
024 7 _ |a 10.1016/j.neulet.2023.137456
|2 doi
024 7 _ |a 0304-3940
|2 ISSN
024 7 _ |a 1872-7972
|2 ISSN
024 7 _ |a 10.34734/FZJ-2023-04873
|2 datacite_doi
024 7 _ |a 37648059
|2 pmid
024 7 _ |a WOS:001069379900001
|2 WOS
037 _ _ |a FZJ-2023-04873
082 _ _ |a 610
100 1 _ |a Kohle, Felix
|0 0000-0002-4429-0367
|b 0
|e Corresponding author
245 _ _ |a 2,4-Dinitrophenol does not exert neuro-regenerative potential in experimental autoimmune neuritis
260 _ _ |a Amsterdam [u.a.]
|c 2023
|b Elsevier Science
336 7 _ |a article
|2 DRIVER
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|b journal
|m journal
|0 PUB:(DE-HGF)16
|s 1701182885_23345
|2 PUB:(DE-HGF)
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a Journal Article
|0 0
|2 EndNote
520 _ _ |a Objective: We evaluated the potential neuro-regenerative effects of the mitochondrial uncoupler 2,4-Dinitrophenol in experimental autoimmune neuritis, an animal model for an acute autoimmune neuropathy.Methods: Experimental autoimmune neuritis was induced in Lewis rats. Different concentrations of 2,4-Dinitrophenol (1 mg/kg, 0.1 mg/kg and 0.01 mg/kg) were applied during the recovery phase of the neuritis (at days 18, 22 and 26) and compared to the vehicle. Any effects were assessed through functional, electrophysiological, and morphological analysis via electron microscopy of all groups at day 30. Additional immune-histochemical analysis of inflammation markers and remyelination of the sciatic nerves were performed for the dosage of 1 mg/kg and control.Results: No enhancement of functional or electrophysiological recovery was observed in all 2,4-Dinitrophenol-treated groups. Cellular inflammation markers of T cells (CD3+) were comparable to control, and an increase of macrophages (IbA1+) invasion in the sciatic nerves was observed. Treatment with 2,4-Dinitrophenol reduced axonal swelling in myelinated and unmyelinated fibers with an increased production of brain-derived neurotrophic factor.Conclusion: Our findings do not support the hypothesis that repurposing of the mitochondrial uncoupler 2,4-Dinitrophenol exerts functionally relevant neuro-regenerative effects in autoimmune neuritis.Keywords: Autoimmune neuropathy; Brain-derived neurotrophic factor; Drug repurposing; Guillain-Barré syndrome; Mitochondrial uncoupler; Neuroregeneration.
536 _ _ |a 5251 - Multilevel Brain Organization and Variability (POF4-525)
|0 G:(DE-HGF)POF4-5251
|c POF4-525
|f POF IV
|x 0
588 _ _ |a Dataset connected to CrossRef, Journals: juser.fz-juelich.de
700 1 _ |a Ackfeld, Robin
|0 P:(DE-HGF)0
|b 1
700 1 _ |a Klein, Ines
|0 P:(DE-HGF)0
|b 2
700 1 _ |a Svačina, Martin K. R.
|0 P:(DE-HGF)0
|b 3
700 1 _ |a Schneider, Christian
|b 4
700 1 _ |a van Beers, Tim
|0 P:(DE-HGF)0
|b 5
700 1 _ |a Grandoch, Andrea
|0 P:(DE-HGF)0
|b 6
700 1 _ |a Fink, Gereon R.
|0 P:(DE-Juel1)131720
|b 7
700 1 _ |a Lehmann, Helmar C.
|0 P:(DE-HGF)0
|b 8
700 1 _ |a Barham, Mohammed
|0 P:(DE-HGF)0
|b 9
773 _ _ |a 10.1016/j.neulet.2023.137456
|g Vol. 814, p. 137456 -
|0 PERI:(DE-600)1498535-4
|p 137456 -
|t Neuroscience letters
|v 814
|y 2023
|x 0304-3940
856 4 _ |u https://juser.fz-juelich.de/record/1018545/files/PDF-12.pdf
856 4 _ |y OpenAccess
|u https://juser.fz-juelich.de/record/1018545/files/POST%20PRINT.pdf
856 4 _ |y OpenAccess
|x icon
|u https://juser.fz-juelich.de/record/1018545/files/POST%20PRINT.gif?subformat=icon
856 4 _ |y OpenAccess
|x icon-1440
|u https://juser.fz-juelich.de/record/1018545/files/POST%20PRINT.jpg?subformat=icon-1440
856 4 _ |y OpenAccess
|x icon-180
|u https://juser.fz-juelich.de/record/1018545/files/POST%20PRINT.jpg?subformat=icon-180
856 4 _ |y OpenAccess
|x icon-640
|u https://juser.fz-juelich.de/record/1018545/files/POST%20PRINT.jpg?subformat=icon-640
856 4 _ |x icon
|u https://juser.fz-juelich.de/record/1018545/files/PDF-12.gif?subformat=icon
856 4 _ |x icon-1440
|u https://juser.fz-juelich.de/record/1018545/files/PDF-12.jpg?subformat=icon-1440
856 4 _ |x icon-180
|u https://juser.fz-juelich.de/record/1018545/files/PDF-12.jpg?subformat=icon-180
856 4 _ |x icon-640
|u https://juser.fz-juelich.de/record/1018545/files/PDF-12.jpg?subformat=icon-640
909 C O |o oai:juser.fz-juelich.de:1018545
|p openaire
|p open_access
|p VDB
|p driver
|p dnbdelivery
910 1 _ |a UK Köln
|0 I:(DE-HGF)0
|b 0
|6 0000-0002-4429-0367
910 1 _ |a Forschungszentrum Jülich
|0 I:(DE-588b)5008462-8
|k FZJ
|b 7
|6 P:(DE-Juel1)131720
913 1 _ |a DE-HGF
|b Key Technologies
|l Natural, Artificial and Cognitive Information Processing
|1 G:(DE-HGF)POF4-520
|0 G:(DE-HGF)POF4-525
|3 G:(DE-HGF)POF4
|2 G:(DE-HGF)POF4-500
|4 G:(DE-HGF)POF
|v Decoding Brain Organization and Dysfunction
|9 G:(DE-HGF)POF4-5251
|x 0
914 1 _ |y 2023
915 _ _ |a OpenAccess
|0 StatID:(DE-HGF)0510
|2 StatID
915 _ _ |a Nationallizenz
|0 StatID:(DE-HGF)0420
|2 StatID
|d 2023-10-21
|w ger
915 _ _ |a JCR
|0 StatID:(DE-HGF)0100
|2 StatID
|b NEUROSCI LETT : 2022
|d 2023-10-21
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0200
|2 StatID
|b SCOPUS
|d 2023-10-21
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0300
|2 StatID
|b Medline
|d 2023-10-21
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0600
|2 StatID
|b Ebsco Academic Search
|d 2023-10-21
915 _ _ |a Peer Review
|0 StatID:(DE-HGF)0030
|2 StatID
|b ASC
|d 2023-10-21
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0199
|2 StatID
|b Clarivate Analytics Master Journal List
|d 2023-10-21
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1050
|2 StatID
|b BIOSIS Previews
|d 2023-10-21
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0150
|2 StatID
|b Web of Science Core Collection
|d 2023-10-21
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1030
|2 StatID
|b Current Contents - Life Sciences
|d 2023-10-21
915 _ _ |a IF < 5
|0 StatID:(DE-HGF)9900
|2 StatID
|d 2023-10-21
920 _ _ |l yes
920 1 _ |0 I:(DE-Juel1)INM-3-20090406
|k INM-3
|l Kognitive Neurowissenschaften
|x 0
980 _ _ |a journal
980 _ _ |a VDB
980 _ _ |a UNRESTRICTED
980 _ _ |a I:(DE-Juel1)INM-3-20090406
980 1 _ |a FullTexts

LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21