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001018610 1001_ $$0P:(DE-Juel1)192260$$aLotter, Leon$$b0$$eCorresponding author
001018610 245__ $$aHuman cortex development is shaped by molecular and cellular brain systems
001018610 260__ $$c2023
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001018610 520__ $$aHuman brain morphology undergoes complex changes over the lifespan. Despite recent progress in tracking brain development via normative models, current knowledge of underlying biological mechanisms is highly limited. We demonstrate that human cerebral cortex development unfolds along patterns of molecular and cellular brain organization, traceable from population-level to individual developmental trajectories. During childhood and adolescence, cortex-wide spatial distributions of dopaminergic receptors, inhibitory neurons, glial cell populations, and brain-metabolic features explain up to 50% of variance associated with regional cortical thickness trajectories. Adult cortical change patterns are best explained by cholinergic and glutamatergic neurotransmission. These relationships are supported by developmental gene expression trajectories and translate to longitudinal data from over 8,000 adolescents, explaining up to 59% of developmental change at population- and 18% at single-subject level. Integrating multilevel brain atlases with normative modeling and population neuroimaging provides a biologically meaningful path to understand typical and atypical brain development in living humans.
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001018610 7001_ $$0P:(DE-Juel1)190448$$aSaberi, Amin$$b1$$ufzj
001018610 7001_ $$00000-0003-3142-7480$$aHansen, Justine Y.$$b2
001018610 7001_ $$00000-0003-0307-2862$$aMisic, Bratislav$$b3
001018610 7001_ $$0P:(DE-Juel1)187055$$aPaquola, Casey$$b4
001018610 7001_ $$aBarker, Gareth J.$$b5
001018610 7001_ $$aBokde, Arun L. W.$$b6
001018610 7001_ $$aDesrivières, Sylvane$$b7
001018610 7001_ $$aFlor, Herta$$b8
001018610 7001_ $$aGrigis, Antoine$$b9
001018610 7001_ $$aGaravan, Hugh$$b10
001018610 7001_ $$aGowland, Penny$$b11
001018610 7001_ $$aHeinz, Andreas$$b12
001018610 7001_ $$aBrühl, Rüdiger$$b13
001018610 7001_ $$aMartinot, Jean-Luc$$b14
001018610 7001_ $$aPaillère, Marie-Laure$$b15
001018610 7001_ $$aArtiges, Eric$$b16
001018610 7001_ $$aOrfanos, Dimitri Papadopoulos$$b17
001018610 7001_ $$aPaus, Tomáš$$b18
001018610 7001_ $$aPoustka, Luise$$b19
001018610 7001_ $$aHohmann, Sarah$$b20
001018610 7001_ $$aFröhner, Juliane H.$$b21
001018610 7001_ $$00000-0001-5398-5569$$aSmolka, Michael N.$$b22
001018610 7001_ $$aVaidya, Nilakshi$$b23
001018610 7001_ $$aWalter, Henrik$$b24
001018610 7001_ $$aWhelan, Robert$$b25
001018610 7001_ $$aSchumann, Gunter$$b26
001018610 7001_ $$00000-0002-7796-8234$$aNees, Frauke$$b27
001018610 7001_ $$00000-0003-4595-1144$$aBanaschewski, Tobias$$b28
001018610 7001_ $$0P:(DE-Juel1)131678$$aEickhoff, Simon B.$$b29
001018610 7001_ $$0P:(DE-Juel1)177727$$aDukart, Juergen$$b30
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