TY  - EJOUR
AU  - Lotter, Leon
AU  - Saberi, Amin
AU  - Hansen, Justine Y.
AU  - Misic, Bratislav
AU  - Paquola, Casey
AU  - Barker, Gareth J.
AU  - Bokde, Arun L. W.
AU  - Desrivières, Sylvane
AU  - Flor, Herta
AU  - Grigis, Antoine
AU  - Garavan, Hugh
AU  - Gowland, Penny
AU  - Heinz, Andreas
AU  - Brühl, Rüdiger
AU  - Martinot, Jean-Luc
AU  - Paillère, Marie-Laure
AU  - Artiges, Eric
AU  - Orfanos, Dimitri Papadopoulos
AU  - Paus, Tomáš
AU  - Poustka, Luise
AU  - Hohmann, Sarah
AU  - Fröhner, Juliane H.
AU  - Smolka, Michael N.
AU  - Vaidya, Nilakshi
AU  - Walter, Henrik
AU  - Whelan, Robert
AU  - Schumann, Gunter
AU  - Nees, Frauke
AU  - Banaschewski, Tobias
AU  - Eickhoff, Simon B.
AU  - Dukart, Juergen
TI  - Human cortex development is shaped by molecular and cellular brain systems
M1  - FZJ-2023-04925
PY  - 2023
AB  - Human brain morphology undergoes complex changes over the lifespan. Despite recent progress in tracking brain development via normative models, current knowledge of underlying biological mechanisms is highly limited. We demonstrate that human cerebral cortex development unfolds along patterns of molecular and cellular brain organization, traceable from population-level to individual developmental trajectories. During childhood and adolescence, cortex-wide spatial distributions of dopaminergic receptors, inhibitory neurons, glial cell populations, and brain-metabolic features explain up to 50% of variance associated with regional cortical thickness trajectories. Adult cortical change patterns are best explained by cholinergic and glutamatergic neurotransmission. These relationships are supported by developmental gene expression trajectories and translate to longitudinal data from over 8,000 adolescents, explaining up to 59% of developmental change at population- and 18% at single-subject level. Integrating multilevel brain atlases with normative modeling and population neuroimaging provides a biologically meaningful path to understand typical and atypical brain development in living humans.
LB  - PUB:(DE-HGF)25
DO  - DOI:10.1101/2023.05.05.539537
UR  - https://juser.fz-juelich.de/record/1018610
ER  -