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@ARTICLE{Lotter:1018610,
      author       = {Lotter, Leon and Saberi, Amin and Hansen, Justine Y. and
                      Misic, Bratislav and Paquola, Casey and Barker, Gareth J.
                      and Bokde, Arun L. W. and Desrivières, Sylvane and Flor,
                      Herta and Grigis, Antoine and Garavan, Hugh and Gowland,
                      Penny and Heinz, Andreas and Brühl, Rüdiger and Martinot,
                      Jean-Luc and Paillère, Marie-Laure and Artiges, Eric and
                      Orfanos, Dimitri Papadopoulos and Paus, Tomáš and Poustka,
                      Luise and Hohmann, Sarah and Fröhner, Juliane H. and
                      Smolka, Michael N. and Vaidya, Nilakshi and Walter, Henrik
                      and Whelan, Robert and Schumann, Gunter and Nees, Frauke and
                      Banaschewski, Tobias and Eickhoff, Simon B. and Dukart,
                      Juergen},
      title        = {{H}uman cortex development is shaped by molecular and
                      cellular brain systems},
      reportid     = {FZJ-2023-04925},
      year         = {2023},
      abstract     = {Human brain morphology undergoes complex changes over the
                      lifespan. Despite recent progress in tracking brain
                      development via normative models, current knowledge of
                      underlying biological mechanisms is highly limited. We
                      demonstrate that human cerebral cortex development unfolds
                      along patterns of molecular and cellular brain organization,
                      traceable from population-level to individual developmental
                      trajectories. During childhood and adolescence, cortex-wide
                      spatial distributions of dopaminergic receptors, inhibitory
                      neurons, glial cell populations, and brain-metabolic
                      features explain up to $50\%$ of variance associated with
                      regional cortical thickness trajectories. Adult cortical
                      change patterns are best explained by cholinergic and
                      glutamatergic neurotransmission. These relationships are
                      supported by developmental gene expression trajectories and
                      translate to longitudinal data from over 8,000 adolescents,
                      explaining up to $59\%$ of developmental change at
                      population- and $18\%$ at single-subject level. Integrating
                      multilevel brain atlases with normative modeling and
                      population neuroimaging provides a biologically meaningful
                      path to understand typical and atypical brain development in
                      living humans.},
      cin          = {INM-7},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)25},
      doi          = {10.1101/2023.05.05.539537},
      url          = {https://juser.fz-juelich.de/record/1018610},
}