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@ARTICLE{Premi:1019087,
      author       = {Premi, Enrico and Pengo, Marta and Mattioli, Irene and
                      Cantoni, Valentina and Dukart, Jürgen and Gasparotti,
                      Roberto and Buratti, Emanuele and Padovani, Alessandro and
                      Bocchetta, Martina and Todd, Emily G. and Bouzigues,
                      Arabella and Cash, David M. and Convery, Rhian S. and
                      Russell, Lucy L. and Foster, Phoebe and Thomas, David L. and
                      van Swieten, John C. and Jiskoot, Lize C. and Seelaar, Harro
                      and Galimberti, Daniela and Sanchez-Valle, Raquel and
                      Laforce, Robert and Moreno, Fermin and Synofzik, Matthis and
                      Graff, Caroline and Masellis, Mario and Tartaglia, Maria
                      Carmela and Rowe, James B. and Tsvetanov, Kamen A. and
                      Vandenberghe, Rik and Finger, Elizabeth and Tiraboschi,
                      Pietro and de Mendonça, Alexandre and Santana, Isabel and
                      Butler, Chris R. and Ducharme, Simon and Gerhard, Alexander
                      and Levin, Johannes and Otto, Markus and Sorbi, Sandro and
                      Le Ber, Isabelle and Pasquier, Florence and Rohrer, Jonathan
                      D. and Borroni, Barbara and Esteve, Aitana Sogorb and
                      Heller, Carolin and Greaves, Caroline V. and Zetterberg,
                      Henrik and Swift, Imogen J. and Samra, Kiran and Shafei,
                      Rachelle and Timberlake, Carolyn and Cope, Thomas and
                      Rittman, Timothy and Arighi, Andrea and Fenoglio, Chiara and
                      Scarpini, Elio and Fumagalli, Giorgio and Borracci, Vittoria
                      and Rossi, Giacomina and Giaccone, Giorgio and Di Fede,
                      Giuseppe and Caroppo, Paola and Tiraboschi, Pietro and
                      Prioni, Sara and Redaelli, Veronica and Tang-Wai, David and
                      Rogaeva, Ekaterina and Castelo-Branco, Miguel and Freedman,
                      Morris and Keren, Ron and Black, Sandra and Mitchell, Sara
                      and Shoesmith, Christen and Bartha, Robart and Rademakers,
                      Rosa and Poos, Jackie and Papma, Janne M. and Giannini,
                      Lucia and van Minkelen, Rick and Pijnenburg, Yolande and
                      Nacmias, Benedetta and Ferrari, Camilla and Polito, Cristina
                      and Lombardi, Gemma and Bessi, Valentina and Veldsman,
                      Michele and Andersson, Christin and Thonberg, Hakan and
                      Öijerstedt, Linn and Jelic, Vesna and Thompson, Paul and
                      Langheinrich, Tobias and Lladó, Albert and Antonell, Anna
                      and Olives, Jaume and Balasa, Mircea and Bargalló, Nuria
                      and Borrego-Ecija, Sergi and Verdelho, Ana and Maruta,
                      Carolina and Ferreira, Catarina B. and Miltenberger, Gabriel
                      and do Couto, Frederico Simões and Gabilondo, Alazne and
                      Gorostidi, Ana and Villanua, Jorge and Cañada, Marta and
                      Tainta, Mikel and Zulaica, Miren and Barandiaran, Myriam and
                      Alves, Patricia and Bender, Benjamin and Wilke, Carlo and
                      Graf, Lisa and Vogels, Annick and Vandenbulcke, Mathieu and
                      Van Damme, Philip and Bruffaerts, Rose and Poesen, Koen and
                      Rosa-Neto, Pedro and Gauthier, Serge and Camuzat, Agnès and
                      Brice, Alexis and Bertrand, Anne and Funkiewiez, Aurélie
                      and Rinaldi, Daisy and Saracino, Dario and Colliot, Olivier
                      and Sayah, Sabrina and Prix, Catharina and Wlasich,
                      Elisabeth and Wagemann, Olivia and Loosli, Sandra and
                      Schönecker, Sonja and Hoegen, Tobias and Lombardi, Jolina
                      and Anderl-Straub, Sarah and Rollin, Adeline and Kuchcinski,
                      Gregory and Bertoux, Maxime and Lebouvier, Thibaud and
                      Deramecourt, Vincent and Santiago, Beatriz and Duro, Diana
                      and Leitão, Maria João and Almeida, Maria Rosario and
                      Tábuas-Pereira, Miguel and Afonso, Sónia},
      title        = {{E}arly neurotransmitters changes in prodromal
                      frontotemporal dementia: {A} {GENFI} study},
      journal      = {Neurobiology of disease},
      volume       = {179},
      issn         = {0969-9961},
      address      = {[Amsterdam]},
      publisher    = {Elsevier},
      reportid     = {FZJ-2023-05140},
      pages        = {106068 -},
      year         = {2023},
      abstract     = {BackgroundNeurotransmitters deficits in Frontotemporal
                      Dementia (FTD) are still poorly understood. Better knowledge
                      of neurotransmitters impairment, especially in prodromal
                      disease stages, might tailor symptomatic treatment
                      approaches.MethodsIn the present study, we applied JuSpace
                      toolbox, which allowed for cross-modal correlation of
                      Magnetic Resonance Imaging (MRI)-based measures with nuclear
                      imaging derived estimates covering various neurotransmitter
                      systems including dopaminergic, serotonergic, noradrenergic,
                      GABAergic and glutamatergic neurotransmission.We included
                      392 mutation carriers (157 GRN, 164 C9orf72, 71 MAPT),
                      together with 276 non-carrier cognitively healthy controls
                      (HC). We tested if the spatial patterns of grey matter
                      volume (GMV) alterations in mutation carriers (relative to
                      HC) are correlated with specific neurotransmitter systems in
                      prodromal (CDR® plus NACC FTLD = 0.5) and in symptomatic
                      (CDR® plus NACC FTLD≥1) FTD.ResultsIn prodromal stages of
                      C9orf72 disease, voxel-based brain changes were
                      significantly associated with spatial distribution of
                      dopamine and acetylcholine pathways; in prodromal MAPT
                      disease with dopamine and serotonin pathways, while in
                      prodromal GRN disease no significant findings were reported
                      (p < 0.05, Family Wise Error corrected). In symptomatic FTD,
                      a widespread involvement of dopamine, serotonin, glutamate
                      and acetylcholine pathways across all genetic subtypes was
                      found. Social cognition scores, loss of empathy and poor
                      response to emotional cues were found to correlate with the
                      strength of GMV colocalization of dopamine and serotonin
                      pathways (all p < 0.01).ConclusionsThis study, indirectly
                      assessing neurotransmitter deficits in monogenic FTD,
                      provides novel insight into disease mechanisms and might
                      suggest potential therapeutic targets to counteract
                      disease-related symptoms.},
      cin          = {INM-7},
      ddc          = {570},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5252},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {36898614},
      UT           = {WOS:000956609800001},
      doi          = {10.1016/j.nbd.2023.106068},
      url          = {https://juser.fz-juelich.de/record/1019087},
}