TY  - JOUR
AU  - Premi, Enrico
AU  - Dukart, Juergen
AU  - Mattioli, Irene
AU  - Libri, Ilenia
AU  - Pengo, Marta
AU  - Gadola, Yasmine
AU  - Cotelli, Maria
AU  - Manenti, Rosa
AU  - Binetti, Giuliano
AU  - Gazzina, Stefano
AU  - Alberici, Antonella
AU  - Magoni, Mauro
AU  - Koch, Giacomo
AU  - Gasparotti, Roberto
AU  - Padovani, Alessandro
AU  - Borroni, Barbara
TI  - Unravelling neurotransmitters impairment in primary progressive aphasias
JO  - Human brain mapping
VL  - 44
IS  - 6
SN  - 1065-9471
CY  - New York, NY
PB  - Wiley-Liss
M1  - FZJ-2023-05142
SP  - 2245 - 2253
PY  - 2023
AB  - Primary progressive aphasias (PPAs) are a group of neurodegenerative diseases mainly characterized by language impairment, and with variably presence of dysexecutive syndrome, behavioural disturbances and parkinsonism. Detailed knowledge of neurotransmitters impairment and its association with clinical features hold the potential to develop new tailored therapeutic approaches. In the present study, we applied JuSpace toolbox, which allowed for cross-modal correlation of magnetic resonance imaging (MRI)-based measures with nuclear imaging derived estimates covering various neurotransmitter systems including dopaminergic, serotonergic, noradrenergic, GABAergic and glutamatergic neurotransmission. We included 103 PPA patients and 80 age-matched healthy controls (HC). We tested if the spatial patterns of grey matter volume (GMV) alterations in PPA patients (relative to HC) are correlated with specific neurotransmitter systems. As compared to HC, voxel-based brain changes in PPA were significantly associated with spatial distribution of serotonin, dopamine, and glutamatergic pathways (p < .05, False Discovery Rate corrected-corrected). Disease severity was negatively correlated with the strength of GMV colocalization of D1 receptors (p = .035) and serotonin transporter (p = .020). Moreover, we observed a significant negative correlation between positive behavioural symptoms, as measured with Frontal Behavioural Inventory, and GMV colocalization of D1 receptors (p = .007) and serotonin transporter (p < .001). This pilot study suggests that JuSpace is a helpful tool to indirectly assess neurotransmitter deficits in neurodegenerative dementias and may provide novel insight into disease mechanisms and associated clinical features.
LB  - PUB:(DE-HGF)16
C6  - 36649260
UR  - <Go to ISI:>//WOS:000987490900001
DO  - DOI:10.1002/hbm.26206
UR  - https://juser.fz-juelich.de/record/1019089
ER  -