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@ARTICLE{Premi:1019089,
      author       = {Premi, Enrico and Dukart, Juergen and Mattioli, Irene and
                      Libri, Ilenia and Pengo, Marta and Gadola, Yasmine and
                      Cotelli, Maria and Manenti, Rosa and Binetti, Giuliano and
                      Gazzina, Stefano and Alberici, Antonella and Magoni, Mauro
                      and Koch, Giacomo and Gasparotti, Roberto and Padovani,
                      Alessandro and Borroni, Barbara},
      title        = {{U}nravelling neurotransmitters impairment in primary
                      progressive aphasias},
      journal      = {Human brain mapping},
      volume       = {44},
      number       = {6},
      issn         = {1065-9471},
      address      = {New York, NY},
      publisher    = {Wiley-Liss},
      reportid     = {FZJ-2023-05142},
      pages        = {2245 - 2253},
      year         = {2023},
      abstract     = {Primary progressive aphasias (PPAs) are a group of
                      neurodegenerative diseases mainly characterized by language
                      impairment, and with variably presence of dysexecutive
                      syndrome, behavioural disturbances and parkinsonism.
                      Detailed knowledge of neurotransmitters impairment and its
                      association with clinical features hold the potential to
                      develop new tailored therapeutic approaches. In the present
                      study, we applied JuSpace toolbox, which allowed for
                      cross-modal correlation of magnetic resonance imaging
                      (MRI)-based measures with nuclear imaging derived estimates
                      covering various neurotransmitter systems including
                      dopaminergic, serotonergic, noradrenergic, GABAergic and
                      glutamatergic neurotransmission. We included 103 PPA
                      patients and 80 age-matched healthy controls (HC). We tested
                      if the spatial patterns of grey matter volume (GMV)
                      alterations in PPA patients (relative to HC) are correlated
                      with specific neurotransmitter systems. As compared to HC,
                      voxel-based brain changes in PPA were significantly
                      associated with spatial distribution of serotonin, dopamine,
                      and glutamatergic pathways (p < .05, False Discovery Rate
                      corrected-corrected). Disease severity was negatively
                      correlated with the strength of GMV colocalization of D1
                      receptors (p = .035) and serotonin transporter (p
                      = .020). Moreover, we observed a significant negative
                      correlation between positive behavioural symptoms, as
                      measured with Frontal Behavioural Inventory, and GMV
                      colocalization of D1 receptors (p = .007) and serotonin
                      transporter (p < .001). This pilot study suggests that
                      JuSpace is a helpful tool to indirectly assess
                      neurotransmitter deficits in neurodegenerative dementias and
                      may provide novel insight into disease mechanisms and
                      associated clinical features.},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5252},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {36649260},
      UT           = {WOS:000987490900001},
      doi          = {10.1002/hbm.26206},
      url          = {https://juser.fz-juelich.de/record/1019089},
}