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@ARTICLE{Passiatore:1019091,
      author       = {Passiatore, Roberta and Antonucci, Linda A. and DeRamus,
                      Thomas P. and Fazio, Leonardo and Stolfa, Giuseppe and
                      Sportelli, Leonardo and Kikidis, Gianluca C. and Blasi,
                      Giuseppe and Chen, Qiang and Dukart, Juergen and Goldman,
                      Aaron L. and Mattay, Venkata S. and Popolizio, Teresa and
                      Rampino, Antonio and Sambataro, Fabio and Selvaggi,
                      Pierluigi and Ulrich, William and Weinberger, Daniel R. and
                      Bertolino, Alessandro and Calhoun, Vince D. and Pergola,
                      Giulio},
      title        = {{C}hanges in patterns of age-related network connectivity
                      are associated with risk for schizophrenia},
      journal      = {Proceedings of the National Academy of Sciences of the
                      United States of America},
      volume       = {120},
      number       = {32},
      issn         = {0027-8424},
      address      = {Washington, DC},
      publisher    = {National Acad. of Sciences},
      reportid     = {FZJ-2023-05144},
      pages        = {e2221533120},
      year         = {2023},
      abstract     = {Alterations in fMRI-based brain functional network
                      connectivity (FNC) are associated with schizophrenia (SCZ)
                      and the genetic risk or subthreshold clinical symptoms
                      preceding the onset of SCZ, which often occurs in early
                      adulthood. Thus, age-sensitive FNC changes may be relevant
                      to SCZ risk-related FNC. We used independent component
                      analysis to estimate FNC from childhood to adulthood in
                      9,236 individuals. To capture individual brain features more
                      accurately than single-session fMRI, we studied an average
                      of three fMRI scans per individual. To identify potential
                      familial risk–related FNC changes, we compared age-related
                      FNC in first-degree relatives of SCZ patients mostly
                      including unaffected siblings (SIB) with neurotypical
                      controls (NC) at the same age stage. Then, we examined how
                      polygenic risk scores for SCZ influenced risk-related FNC
                      patterns. Finally, we investigated the same risk-related FNC
                      patterns in adult SCZ patients (oSCZ) and young individuals
                      with subclinical psychotic symptoms (PSY). Age-sensitive
                      risk-related FNC patterns emerge during adolescence and
                      early adulthood, but not before. Young SIB always followed
                      older NC patterns, with decreased FNC in a
                      cerebellar–occipitoparietal circuit and increased FNC in
                      two prefrontal–sensorimotor circuits when compared to
                      young NC. Two of these FNC alterations were also found in
                      oSCZ, with one exhibiting reversed pattern. All were linked
                      to polygenic risk for SCZ in unrelated individuals (R2
                      varied from 0.02 to 0.05). Young PSY showed FNC alterations
                      in the same direction as SIB when compared to NC. These
                      results suggest that age-related neurotypical FNC correlates
                      with genetic risk for SCZ and is detectable with MRI in
                      young participants.},
      cin          = {INM-7},
      ddc          = {500},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5252},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {37527347},
      UT           = {WOS:001083463000007},
      doi          = {10.1073/pnas.2221533120},
      url          = {https://juser.fz-juelich.de/record/1019091},
}