001019092 001__ 1019092
001019092 005__ 20240116084327.0
001019092 0247_ $$2doi$$a10.1002/hbm.26451
001019092 0247_ $$2ISSN$$a1065-9471
001019092 0247_ $$2ISSN$$a1097-0193
001019092 0247_ $$2datacite_doi$$a10.34734/FZJ-2023-05145
001019092 0247_ $$2pmid$$a37608591
001019092 0247_ $$2WOS$$aWOS:001052388000001
001019092 037__ $$aFZJ-2023-05145
001019092 082__ $$a610
001019092 1001_ $$0P:(DE-HGF)0$$aSchinz, David$$b0$$eCorresponding author
001019092 245__ $$aIndirect evidence for altered dopaminergic neurotransmission in very premature‐born adults
001019092 260__ $$aNew York, NY$$bWiley-Liss$$c2023
001019092 3367_ $$2DRIVER$$aarticle
001019092 3367_ $$2DataCite$$aOutput Types/Journal article
001019092 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1702554803_9947
001019092 3367_ $$2BibTeX$$aARTICLE
001019092 3367_ $$2ORCID$$aJOURNAL_ARTICLE
001019092 3367_ $$00$$2EndNote$$aJournal Article
001019092 500__ $$aResearch funding: Bundesministerium für Bildung und Forschung. Grant Numbers: BMBF 01ER0801, BMBF 01ER0803, Deutsche Forschungsgemeinschaft. Grant Number: SO1336/1-1, Horizon 2020 Framework Programme. Grant Number: 733280, Kommission für Klinische Forschung, Technische Universität München. Grant Numbers: 8700000474, 8765162
001019092 520__ $$aWhile animal models indicate altered brain dopaminergic neurotransmission after premature birth, corresponding evidence in humans is scarce due to missing molecular imaging studies. To overcome this limitation, we studied dopaminergic neurotransmission changes in human prematurity indirectly by evaluating the spatial co-localization of regional alterations in blood oxygenation fluctuations with the distribution of adult dopaminergic neurotransmission. The study cohort comprised 99 very premature-born (<32 weeks of gestation and/or birth weight below 1500 g) and 107 full-term born young adults, being assessed by resting-state functional MRI (rs-fMRI) and IQ testing. Normative molecular imaging dopamine neurotransmission maps were derived from independent healthy control groups. We computed the co-localization of local (rs-fMRI) activity alterations in premature-born adults with respect to term-born individuals to different measures of dopaminergic neurotransmission. We performed selectivity analyses regarding other neuromodulatory systems and MRI measures. In addition, we tested if the strength of the co-localization is related to perinatal measures and IQ. We found selectively altered co-localization of rs-fMRI activity in the premature-born cohort with dopamine-2/3-receptor availability in premature-born adults. Alterations were specific for the dopaminergic system but not for the used MRI measure. The strength of the co-localization was negatively correlated with IQ. In line with animal studies, our findings support the notion of altered dopaminergic neurotransmission in prematurity which is associated with cognitive performance.
001019092 536__ $$0G:(DE-HGF)POF4-5252$$a5252 - Brain Dysfunction and Plasticity (POF4-525)$$cPOF4-525$$fPOF IV$$x0
001019092 588__ $$aDataset connected to CrossRef, Journals: juser.fz-juelich.de
001019092 7001_ $$0P:(DE-HGF)0$$aSchmitz-Koep, Benita$$b1
001019092 7001_ $$0P:(DE-HGF)0$$aZimmermann, Juliana$$b2
001019092 7001_ $$0P:(DE-HGF)0$$aBrandes, Elin$$b3
001019092 7001_ $$0P:(DE-HGF)0$$aTahedl, Marlene$$b4
001019092 7001_ $$0P:(DE-HGF)0$$aMenegaux, Aurore$$b5
001019092 7001_ $$0P:(DE-Juel1)177727$$aDukart, Jürgen$$b6$$ufzj
001019092 7001_ $$0P:(DE-HGF)0$$aZimmer, Claus$$b7
001019092 7001_ $$0P:(DE-HGF)0$$aWolke, Dieter$$b8
001019092 7001_ $$0P:(DE-HGF)0$$aDaamen, Marcel$$b9
001019092 7001_ $$0P:(DE-HGF)0$$aBoecker, Henning$$b10
001019092 7001_ $$0P:(DE-HGF)0$$aBartmann, Peter$$b11
001019092 7001_ $$0P:(DE-HGF)0$$aSorg, Christian$$b12
001019092 7001_ $$0P:(DE-HGF)0$$aHedderich, Dennis M.$$b13
001019092 773__ $$0PERI:(DE-600)1492703-2$$a10.1002/hbm.26451$$gVol. 44, no. 15, p. 5125 - 5138$$n15$$p5125 - 5138$$tHuman brain mapping$$v44$$x1065-9471$$y2023
001019092 8564_ $$uhttps://juser.fz-juelich.de/record/1019092/files/Human%20Brain%20Mapping%20-%202023%20-%20Schinz%20-%20Indirect%20evidence%20for%20altered%20dopaminergic%20neurotransmission%20in%20very%20premature%E2%80%90born.pdf$$yOpenAccess
001019092 8564_ $$uhttps://juser.fz-juelich.de/record/1019092/files/Human%20Brain%20Mapping%20-%202023%20-%20Schinz%20-%20Indirect%20evidence%20for%20altered%20dopaminergic%20neurotransmission%20in%20very%20premature%E2%80%90born.gif?subformat=icon$$xicon$$yOpenAccess
001019092 8564_ $$uhttps://juser.fz-juelich.de/record/1019092/files/Human%20Brain%20Mapping%20-%202023%20-%20Schinz%20-%20Indirect%20evidence%20for%20altered%20dopaminergic%20neurotransmission%20in%20very%20premature%E2%80%90born.jpg?subformat=icon-1440$$xicon-1440$$yOpenAccess
001019092 8564_ $$uhttps://juser.fz-juelich.de/record/1019092/files/Human%20Brain%20Mapping%20-%202023%20-%20Schinz%20-%20Indirect%20evidence%20for%20altered%20dopaminergic%20neurotransmission%20in%20very%20premature%E2%80%90born.jpg?subformat=icon-180$$xicon-180$$yOpenAccess
001019092 8564_ $$uhttps://juser.fz-juelich.de/record/1019092/files/Human%20Brain%20Mapping%20-%202023%20-%20Schinz%20-%20Indirect%20evidence%20for%20altered%20dopaminergic%20neurotransmission%20in%20very%20premature%E2%80%90born.jpg?subformat=icon-640$$xicon-640$$yOpenAccess
001019092 909CO $$ooai:juser.fz-juelich.de:1019092$$pdnbdelivery$$pdriver$$pVDB$$popen_access$$popenaire
001019092 9101_ $$0I:(DE-HGF)0$$6P:(DE-HGF)0$$a Department of Diagnostic and Interventional Neuroradiology, Klinikum rechts der Isar, Technische Universität München$$b0
001019092 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)177727$$aForschungszentrum Jülich$$b6$$kFZJ
001019092 9101_ $$0I:(DE-HGF)0$$6P:(DE-Juel1)177727$$a HHU Düsseldorf$$b6
001019092 9131_ $$0G:(DE-HGF)POF4-525$$1G:(DE-HGF)POF4-520$$2G:(DE-HGF)POF4-500$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$9G:(DE-HGF)POF4-5252$$aDE-HGF$$bKey Technologies$$lNatural, Artificial and Cognitive Information Processing$$vDecoding Brain Organization and Dysfunction$$x0
001019092 9141_ $$y2023
001019092 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
001019092 915__ $$0LIC:(DE-HGF)CCBYNCND4$$2HGFVOC$$aCreative Commons Attribution-NonCommercial-NoDerivs CC BY-NC-ND 4.0
001019092 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz$$d2023-08-25$$wger
001019092 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2023-08-25
001019092 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2023-08-25
001019092 915__ $$0StatID:(DE-HGF)0320$$2StatID$$aDBCoverage$$bPubMed Central$$d2023-08-25
001019092 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal$$d2022-09-27T20:46:01Z
001019092 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ$$d2022-09-27T20:46:01Z
001019092 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bDOAJ : Anonymous peer review$$d2022-09-27T20:46:01Z
001019092 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2023-08-25
001019092 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2023-08-25
001019092 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2023-08-25
001019092 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2023-08-25
001019092 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bHUM BRAIN MAPP : 2022$$d2023-08-25
001019092 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2023-08-25
001019092 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2023-08-25
001019092 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5$$d2023-08-25
001019092 920__ $$lno
001019092 9201_ $$0I:(DE-Juel1)INM-7-20090406$$kINM-7$$lGehirn & Verhalten$$x0
001019092 980__ $$ajournal
001019092 980__ $$aVDB
001019092 980__ $$aUNRESTRICTED
001019092 980__ $$aI:(DE-Juel1)INM-7-20090406
001019092 9801_ $$aFullTexts