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@ARTICLE{Schinz:1019092,
      author       = {Schinz, David and Schmitz-Koep, Benita and Zimmermann,
                      Juliana and Brandes, Elin and Tahedl, Marlene and Menegaux,
                      Aurore and Dukart, Jürgen and Zimmer, Claus and Wolke,
                      Dieter and Daamen, Marcel and Boecker, Henning and Bartmann,
                      Peter and Sorg, Christian and Hedderich, Dennis M.},
      title        = {{I}ndirect evidence for altered dopaminergic
                      neurotransmission in very premature‐born adults},
      journal      = {Human brain mapping},
      volume       = {44},
      number       = {15},
      issn         = {1065-9471},
      address      = {New York, NY},
      publisher    = {Wiley-Liss},
      reportid     = {FZJ-2023-05145},
      pages        = {5125 - 5138},
      year         = {2023},
      note         = {Research funding: Bundesministerium für Bildung und
                      Forschung. Grant Numbers: BMBF 01ER0801, BMBF 01ER0803,
                      Deutsche Forschungsgemeinschaft. Grant Number: SO1336/1-1,
                      Horizon 2020 Framework Programme. Grant Number: 733280,
                      Kommission für Klinische Forschung, Technische Universität
                      München. Grant Numbers: 8700000474, 8765162},
      abstract     = {While animal models indicate altered brain dopaminergic
                      neurotransmission after premature birth, corresponding
                      evidence in humans is scarce due to missing molecular
                      imaging studies. To overcome this limitation, we studied
                      dopaminergic neurotransmission changes in human prematurity
                      indirectly by evaluating the spatial co-localization of
                      regional alterations in blood oxygenation fluctuations with
                      the distribution of adult dopaminergic neurotransmission.
                      The study cohort comprised 99 very premature-born
                      (<32 weeks of gestation and/or birth weight below
                      1500 g) and 107 full-term born young adults, being
                      assessed by resting-state functional MRI (rs-fMRI) and IQ
                      testing. Normative molecular imaging dopamine
                      neurotransmission maps were derived from independent healthy
                      control groups. We computed the co-localization of local
                      (rs-fMRI) activity alterations in premature-born adults with
                      respect to term-born individuals to different measures of
                      dopaminergic neurotransmission. We performed selectivity
                      analyses regarding other neuromodulatory systems and MRI
                      measures. In addition, we tested if the strength of the
                      co-localization is related to perinatal measures and IQ. We
                      found selectively altered co-localization of rs-fMRI
                      activity in the premature-born cohort with
                      dopamine-2/3-receptor availability in premature-born adults.
                      Alterations were specific for the dopaminergic system but
                      not for the used MRI measure. The strength of the
                      co-localization was negatively correlated with IQ. In line
                      with animal studies, our findings support the notion of
                      altered dopaminergic neurotransmission in prematurity which
                      is associated with cognitive performance.},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5252},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {37608591},
      UT           = {WOS:001052388000001},
      doi          = {10.1002/hbm.26451},
      url          = {https://juser.fz-juelich.de/record/1019092},
}