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@ARTICLE{Nmeth:1019095,
      author       = {Németh, Andrea H. and Antoniades, Chrystalina A. and
                      Dukart, Jürgen and Minnerop, Martina and Rentz, Clara and
                      Schuman, Bart-Jan and van de Warrenburg, Bart and Willemse,
                      Ilse and Bertini, Enrico and Gupta, Anoopum S. and de Mello
                      Monteiro, Carlos Bandeira and Almoajil, Hajar and Quinn,
                      Lori and Perlman, Susan B. and Horak, Fay and Ilg, Winfried
                      and Traschütz, Andreas and Vogel, Adam P. and Dawes, Helen},
      title        = {{U}sing {S}martphone {S}ensors for {A}taxia {T}rials:
                      {C}onsensus {G}uidance by the {A}taxia {G}lobal {I}nitiative
                      {W}orking {G}roup on {D}igital-{M}otor {B}iomarkers},
      journal      = {The cerebellum},
      volume       = {23},
      issn         = {1473-4222},
      address      = {New York},
      publisher    = {Springer US},
      reportid     = {FZJ-2023-05148},
      pages        = {912-923},
      year         = {2024},
      abstract     = {Smartphone sensors are used increasingly in the assessment
                      of ataxias. To date, there is no specific consensus guidance
                      regarding a priority set of smartphone sensor measurements,
                      or standard assessment criteria that are appropriate for
                      clinical trials. As part of the Ataxia Global Initiative
                      Digital-Motor Biomarkers Working Group (AGI WG4), aimed at
                      evaluating key ataxia clinical domains (gait/posture, upper
                      limb, speech and oculomotor assessments), we provide
                      consensus guidance for use of internal smartphone sensors to
                      assess key domains. Guidance was developed by means of a
                      literature review and a two stage Delphi study conducted by
                      an Expert panel, which surveyed members of AGI WG4,
                      representing clinical, research, industry and patient-led
                      experts, and consensus meetings by the Expert panel to agree
                      on standard criteria and map current literature to these
                      criteria. Seven publications were identified that
                      investigated ataxias using internal smartphone sensors. The
                      Delphi 1 survey ascertained current practice, and systems in
                      use or under development. Wide variations in smartphones
                      sensor use for assessing ataxia were identified. The Delphi
                      2 survey identified seven measures that were strongly
                      endorsed as priorities in assessing 3/4 domains, namely
                      gait/posture, upper limb, and speech performance. The Expert
                      panel recommended 15 standard criteria to be fulfilled in
                      studies. Evaluation of current literature revealed that none
                      of the studies met all criteria, with most being early-phase
                      validation studies. Our guidance highlights the importance
                      of consensus, identifies priority measures and standard
                      criteria, and will encourage further research into the use
                      of internal smartphone sensors to measure ataxia
                      digital-motor biomarkers.},
      cin          = {INM-7 / INM-1},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406 / I:(DE-Juel1)INM-1-20090406},
      pnm          = {353 - Clinical and Health Care Research (POF4-353) / 5251 -
                      Multilevel Brain Organization and Variability (POF4-525)},
      pid          = {G:(DE-HGF)POF4-353 / G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {38015365},
      UT           = {WOS:001118809700001},
      doi          = {10.1007/s12311-023-01608-3},
      url          = {https://juser.fz-juelich.de/record/1019095},
}