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@ARTICLE{Olazbal:1019143,
      author       = {Olazábal, Daniel Ernesto and Bertoni, Bernardo and Grandi,
                      Graciela and Musetti, Dora and Rey, Grazzia and Sandberg,
                      Natalia and Fernández, Lucia and Laporte, Gabriela and
                      Medici, Florencia and Nicolaisen-Sobesky, Eliana},
      title        = {{O}xytocin system polymorphisms rs237887 and rs2740210
                      variants increase the risk of depression in pregnant women
                      with early abuse},
      journal      = {Developmental psychobiology},
      volume       = {65},
      number       = {5},
      issn         = {0012-1630},
      address      = {New York, NY [u.a.]},
      publisher    = {Wiley},
      reportid     = {FZJ-2023-05191},
      pages        = {e22400},
      year         = {2023},
      abstract     = {Prepartum depression is associated with early adversity,
                      pregnancy complications, preterm delivery, postpartum
                      depression, and long-term effects on child neurodevelopment.
                      The oxytocin (OXT) system is affected by early adverse
                      experiences and has been associated with depression. In the
                      current study, we investigated risk factors for prenatal
                      depressive symptoms, mainly the effects of early childhood
                      and adolescence trauma, in combination with the presence of
                      certain variants of polymorphisms of OXT and OXT receptor
                      (OXTR) genes. We hypothesized that early childhood and
                      adolescence trauma has higher negative effects in carriers
                      of genetic variants of the OXT/OXTR system, increasing their
                      risk for depression. Early in pregnancy (8–14 weeks), 141
                      pregnant women from a Uruguayan population were asked to
                      provide DNA samples and complete questionnaires that
                      assessed their experience of child abuse, depression
                      symptoms, and other variables that included demographic
                      information. Our results showed that $23.5\%$ of pregnant
                      women had depressive symptoms. Several OXT and OXTR genetic
                      variants were associated with higher risk of prepartum
                      depression only in those pregnant women who suffered
                      emotional abuse during infancy or adolescence. Logistic
                      regression (Nagelkerke's R2 = .33) revealed that women who
                      suffered early abuse and were carriers of the variants CC of
                      rs2740210 (OXT) or AA of rs237887 (OXTR) had significantly
                      higher risk of experiencing depressive symptoms. Antecedents
                      of psychiatric disorders also contributed to the risk of
                      depression. We conclude that emotional abuse contributes to
                      the risk of depression in different ways in women carrying
                      different OXT and OXTR genetic variants. Early detection and
                      closer follow-up of women with child abuse and certain OXT
                      genetic variants, among other risk factors, could reduce the
                      long-term impact of prepartum depression.},
      cin          = {INM-7},
      ddc          = {570},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {37338248},
      UT           = {WOS:000989013200001},
      doi          = {10.1002/dev.22400},
      url          = {https://juser.fz-juelich.de/record/1019143},
}