001019154 001__ 1019154
001019154 005__ 20240213111720.0
001019154 0247_ $$2doi$$a10.1016/j.bpsc.2023.06.002
001019154 0247_ $$2ISSN$$a2451-9022
001019154 0247_ $$2ISSN$$a2451-9030
001019154 0247_ $$2datacite_doi$$a10.34734/FZJ-2023-05202
001019154 0247_ $$2pmid$$a37336263
001019154 0247_ $$2WOS$$aWOS:001135945600001
001019154 037__ $$aFZJ-2023-05202
001019154 082__ $$a610
001019154 1001_ $$0P:(DE-HGF)0$$aAlho, Jussi$$b0$$eCorresponding author
001019154 245__ $$aHippocampus-Centered Network Is Associated With Positive Symptom Alleviation in Patients With First-Episode Psychosis
001019154 260__ $$aAmsterdam [u.a.]$$bElsevier Inc.$$c2023
001019154 3367_ $$2DRIVER$$aarticle
001019154 3367_ $$2DataCite$$aOutput Types/Journal article
001019154 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1702555471_2342
001019154 3367_ $$2BibTeX$$aARTICLE
001019154 3367_ $$2ORCID$$aJOURNAL_ARTICLE
001019154 3367_ $$00$$2EndNote$$aJournal Article
001019154 520__ $$aBackgroundPrevious functional magnetic resonance imaging studies have reported widespread brain functional connectivity alterations in patients with psychosis. These studies have mostly used either resting-state or simple-task paradigms, thereby compromising experimental control or ecological validity, respectively. Additionally, in a conventional functional magnetic resonance imaging intrasubject functional connectivity analysis, it is difficult to identify which connections relate to extrinsic (stimulus-induced) and which connections relate to intrinsic (non–stimulus-related) neural processes.MethodsTo mitigate these limitations, we used intersubject functional connectivity (ISFC) to analyze longitudinal functional magnetic resonance imaging data collected while 36 individuals with first-episode psychosis (FEP) and 29 age- and sex-matched population control participants watched scenes from the fantasy movie Alice in Wonderland at baseline and again at 1-year follow-up. Furthermore, to allow unconfounded comparison and to overcome possible circularity of ISFC, we introduced a novel approach wherein ISFC in both the FEP and population control groups was calculated with respect to an independent group of participants (not included in the analyses).ResultsUsing this independent-reference ISFC approach, we found an interaction effect wherein the independent-reference ISFC in individuals with FEP, but not in the control group participants, was significantly stronger at baseline than at follow-up in a network centered in the hippocampus and involving thalamic, striatal, and cortical regions, such as the orbitofrontal cortex. Alleviation of positive symptoms, particularly delusions, from baseline to follow-up was correlated with decreased network connectivity in patients with FEP.ConclusionsThese findings link deviation of naturalistic information processing in the hippocampus-centered network to positive symptoms.
001019154 536__ $$0G:(DE-HGF)POF4-5252$$a5252 - Brain Dysfunction and Plasticity (POF4-525)$$cPOF4-525$$fPOF IV$$x0
001019154 588__ $$aDataset connected to CrossRef, Journals: juser.fz-juelich.de
001019154 7001_ $$0P:(DE-Juel1)179423$$aLahnakoski, Juha M.$$b1
001019154 7001_ $$0P:(DE-HGF)0$$aPanula, Jonatan M.$$b2
001019154 7001_ $$0P:(DE-HGF)0$$aRikandi, Eva$$b3
001019154 7001_ $$0P:(DE-HGF)0$$aMäntylä, Teemu$$b4
001019154 7001_ $$0P:(DE-HGF)0$$aLindgren, Maija$$b5
001019154 7001_ $$0P:(DE-HGF)0$$aKieseppä, Tuula$$b6
001019154 7001_ $$0P:(DE-HGF)0$$aSuvisaari, Jaana$$b7
001019154 7001_ $$0P:(DE-HGF)0$$aSams, Mikko$$b8
001019154 7001_ $$0P:(DE-HGF)0$$aRaij, Tuukka T.$$b9$$eCorresponding author
001019154 773__ $$0PERI:(DE-600)2879089-3$$a10.1016/j.bpsc.2023.06.002$$gVol. 8, no. 12, p. 1197 - 1206$$n12$$p1197 - 1206$$tBiological psychiatry / Cognitive neuroscience and neuroimaging$$v8$$x2451-9022$$y2023
001019154 8564_ $$uhttps://doi.org/10.1016/j.bpsc.2023.06.002
001019154 8564_ $$uhttps://juser.fz-juelich.de/record/1019154/files/1-s2.0-S2451902223001453-main.pdf$$yOpenAccess
001019154 8564_ $$uhttps://juser.fz-juelich.de/record/1019154/files/1-s2.0-S2451902223001453-main.gif?subformat=icon$$xicon$$yOpenAccess
001019154 8564_ $$uhttps://juser.fz-juelich.de/record/1019154/files/1-s2.0-S2451902223001453-main.jpg?subformat=icon-1440$$xicon-1440$$yOpenAccess
001019154 8564_ $$uhttps://juser.fz-juelich.de/record/1019154/files/1-s2.0-S2451902223001453-main.jpg?subformat=icon-180$$xicon-180$$yOpenAccess
001019154 8564_ $$uhttps://juser.fz-juelich.de/record/1019154/files/1-s2.0-S2451902223001453-main.jpg?subformat=icon-640$$xicon-640$$yOpenAccess
001019154 909CO $$ooai:juser.fz-juelich.de:1019154$$pdnbdelivery$$pdriver$$pVDB$$popen_access$$popenaire
001019154 9101_ $$0I:(DE-HGF)0$$6P:(DE-HGF)0$$a Department of Neuroscience and Biomedical Engineering, Aalto University School of Science, Espoo, Finland$$b0
001019154 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)179423$$aForschungszentrum Jülich$$b1$$kFZJ
001019154 9101_ $$0I:(DE-HGF)0$$6P:(DE-HGF)0$$a Department of Neuroscience and Biomedical Engineering, Aalto University School of Science, Espoo, Finland$$b9
001019154 9131_ $$0G:(DE-HGF)POF4-525$$1G:(DE-HGF)POF4-520$$2G:(DE-HGF)POF4-500$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$9G:(DE-HGF)POF4-5252$$aDE-HGF$$bKey Technologies$$lNatural, Artificial and Cognitive Information Processing$$vDecoding Brain Organization and Dysfunction$$x0
001019154 9141_ $$y2023
001019154 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2023-08-24
001019154 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2023-08-24
001019154 915__ $$0LIC:(DE-HGF)CCBY4$$2HGFVOC$$aCreative Commons Attribution CC BY 4.0
001019154 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bBIOL PSYCHIAT-COGN N : 2022$$d2023-08-24
001019154 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2023-08-24
001019154 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
001019154 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5$$bBIOL PSYCHIAT-COGN N : 2022$$d2023-08-24
001019154 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2023-08-24
001019154 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2023-08-24
001019154 915__ $$0StatID:(DE-HGF)1110$$2StatID$$aDBCoverage$$bCurrent Contents - Clinical Medicine$$d2023-08-24
001019154 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2023-08-24
001019154 920__ $$lno
001019154 9201_ $$0I:(DE-Juel1)INM-7-20090406$$kINM-7$$lGehirn & Verhalten$$x0
001019154 980__ $$ajournal
001019154 980__ $$aVDB
001019154 980__ $$aUNRESTRICTED
001019154 980__ $$aI:(DE-Juel1)INM-7-20090406
001019154 9801_ $$aFullTexts