TY  - JOUR
AU  - Alho, Jussi
AU  - Lahnakoski, Juha M.
AU  - Panula, Jonatan M.
AU  - Rikandi, Eva
AU  - Mäntylä, Teemu
AU  - Lindgren, Maija
AU  - Kieseppä, Tuula
AU  - Suvisaari, Jaana
AU  - Sams, Mikko
AU  - Raij, Tuukka T.
TI  - Hippocampus-Centered Network Is Associated With Positive Symptom Alleviation in Patients With First-Episode Psychosis
JO  - Biological psychiatry / Cognitive neuroscience and neuroimaging
VL  - 8
IS  - 12
SN  - 2451-9022
CY  - Amsterdam [u.a.]
PB  - Elsevier Inc.
M1  - FZJ-2023-05202
SP  - 1197 - 1206
PY  - 2023
AB  - BackgroundPrevious functional magnetic resonance imaging studies have reported widespread brain functional connectivity alterations in patients with psychosis. These studies have mostly used either resting-state or simple-task paradigms, thereby compromising experimental control or ecological validity, respectively. Additionally, in a conventional functional magnetic resonance imaging intrasubject functional connectivity analysis, it is difficult to identify which connections relate to extrinsic (stimulus-induced) and which connections relate to intrinsic (non–stimulus-related) neural processes.MethodsTo mitigate these limitations, we used intersubject functional connectivity (ISFC) to analyze longitudinal functional magnetic resonance imaging data collected while 36 individuals with first-episode psychosis (FEP) and 29 age- and sex-matched population control participants watched scenes from the fantasy movie Alice in Wonderland at baseline and again at 1-year follow-up. Furthermore, to allow unconfounded comparison and to overcome possible circularity of ISFC, we introduced a novel approach wherein ISFC in both the FEP and population control groups was calculated with respect to an independent group of participants (not included in the analyses).ResultsUsing this independent-reference ISFC approach, we found an interaction effect wherein the independent-reference ISFC in individuals with FEP, but not in the control group participants, was significantly stronger at baseline than at follow-up in a network centered in the hippocampus and involving thalamic, striatal, and cortical regions, such as the orbitofrontal cortex. Alleviation of positive symptoms, particularly delusions, from baseline to follow-up was correlated with decreased network connectivity in patients with FEP.ConclusionsThese findings link deviation of naturalistic information processing in the hippocampus-centered network to positive symptoms.
LB  - PUB:(DE-HGF)16
C6  - 37336263
UR  - <Go to ISI:>//WOS:001135945600001
DO  - DOI:10.1016/j.bpsc.2023.06.002
UR  - https://juser.fz-juelich.de/record/1019154
ER  -