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@ARTICLE{Alho:1019154,
      author       = {Alho, Jussi and Lahnakoski, Juha M. and Panula, Jonatan M.
                      and Rikandi, Eva and Mäntylä, Teemu and Lindgren, Maija
                      and Kieseppä, Tuula and Suvisaari, Jaana and Sams, Mikko
                      and Raij, Tuukka T.},
      title        = {{H}ippocampus-{C}entered {N}etwork {I}s {A}ssociated {W}ith
                      {P}ositive {S}ymptom {A}lleviation in {P}atients {W}ith
                      {F}irst-{E}pisode {P}sychosis},
      journal      = {Biological psychiatry / Cognitive neuroscience and
                      neuroimaging},
      volume       = {8},
      number       = {12},
      issn         = {2451-9022},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Inc.},
      reportid     = {FZJ-2023-05202},
      pages        = {1197 - 1206},
      year         = {2023},
      abstract     = {BackgroundPrevious functional magnetic resonance imaging
                      studies have reported widespread brain functional
                      connectivity alterations in patients with psychosis. These
                      studies have mostly used either resting-state or simple-task
                      paradigms, thereby compromising experimental control or
                      ecological validity, respectively. Additionally, in a
                      conventional functional magnetic resonance imaging
                      intrasubject functional connectivity analysis, it is
                      difficult to identify which connections relate to extrinsic
                      (stimulus-induced) and which connections relate to intrinsic
                      (non–stimulus-related) neural processes.MethodsTo mitigate
                      these limitations, we used intersubject functional
                      connectivity (ISFC) to analyze longitudinal functional
                      magnetic resonance imaging data collected while 36
                      individuals with first-episode psychosis (FEP) and 29 age-
                      and sex-matched population control participants watched
                      scenes from the fantasy movie Alice in Wonderland at
                      baseline and again at 1-year follow-up. Furthermore, to
                      allow unconfounded comparison and to overcome possible
                      circularity of ISFC, we introduced a novel approach wherein
                      ISFC in both the FEP and population control groups was
                      calculated with respect to an independent group of
                      participants (not included in the analyses).ResultsUsing
                      this independent-reference ISFC approach, we found an
                      interaction effect wherein the independent-reference ISFC in
                      individuals with FEP, but not in the control group
                      participants, was significantly stronger at baseline than at
                      follow-up in a network centered in the hippocampus and
                      involving thalamic, striatal, and cortical regions, such as
                      the orbitofrontal cortex. Alleviation of positive symptoms,
                      particularly delusions, from baseline to follow-up was
                      correlated with decreased network connectivity in patients
                      with FEP.ConclusionsThese findings link deviation of
                      naturalistic information processing in the
                      hippocampus-centered network to positive symptoms.},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5252},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {37336263},
      UT           = {WOS:001135945600001},
      doi          = {10.1016/j.bpsc.2023.06.002},
      url          = {https://juser.fz-juelich.de/record/1019154},
}