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| 001 | 1019154 | ||
| 005 | 20240213111720.0 | ||
| 024 | 7 | _ | |a 10.1016/j.bpsc.2023.06.002 |2 doi |
| 024 | 7 | _ | |a 2451-9022 |2 ISSN |
| 024 | 7 | _ | |a 2451-9030 |2 ISSN |
| 024 | 7 | _ | |a 10.34734/FZJ-2023-05202 |2 datacite_doi |
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| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Alho, Jussi |0 P:(DE-HGF)0 |b 0 |e Corresponding author |
| 245 | _ | _ | |a Hippocampus-Centered Network Is Associated With Positive Symptom Alleviation in Patients With First-Episode Psychosis |
| 260 | _ | _ | |a Amsterdam [u.a.] |c 2023 |b Elsevier Inc. |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1702555471_2342 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a BackgroundPrevious functional magnetic resonance imaging studies have reported widespread brain functional connectivity alterations in patients with psychosis. These studies have mostly used either resting-state or simple-task paradigms, thereby compromising experimental control or ecological validity, respectively. Additionally, in a conventional functional magnetic resonance imaging intrasubject functional connectivity analysis, it is difficult to identify which connections relate to extrinsic (stimulus-induced) and which connections relate to intrinsic (non–stimulus-related) neural processes.MethodsTo mitigate these limitations, we used intersubject functional connectivity (ISFC) to analyze longitudinal functional magnetic resonance imaging data collected while 36 individuals with first-episode psychosis (FEP) and 29 age- and sex-matched population control participants watched scenes from the fantasy movie Alice in Wonderland at baseline and again at 1-year follow-up. Furthermore, to allow unconfounded comparison and to overcome possible circularity of ISFC, we introduced a novel approach wherein ISFC in both the FEP and population control groups was calculated with respect to an independent group of participants (not included in the analyses).ResultsUsing this independent-reference ISFC approach, we found an interaction effect wherein the independent-reference ISFC in individuals with FEP, but not in the control group participants, was significantly stronger at baseline than at follow-up in a network centered in the hippocampus and involving thalamic, striatal, and cortical regions, such as the orbitofrontal cortex. Alleviation of positive symptoms, particularly delusions, from baseline to follow-up was correlated with decreased network connectivity in patients with FEP.ConclusionsThese findings link deviation of naturalistic information processing in the hippocampus-centered network to positive symptoms. |
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| 700 | 1 | _ | |a Lahnakoski, Juha M. |0 P:(DE-Juel1)179423 |b 1 |
| 700 | 1 | _ | |a Panula, Jonatan M. |0 P:(DE-HGF)0 |b 2 |
| 700 | 1 | _ | |a Rikandi, Eva |0 P:(DE-HGF)0 |b 3 |
| 700 | 1 | _ | |a Mäntylä, Teemu |0 P:(DE-HGF)0 |b 4 |
| 700 | 1 | _ | |a Lindgren, Maija |0 P:(DE-HGF)0 |b 5 |
| 700 | 1 | _ | |a Kieseppä, Tuula |0 P:(DE-HGF)0 |b 6 |
| 700 | 1 | _ | |a Suvisaari, Jaana |0 P:(DE-HGF)0 |b 7 |
| 700 | 1 | _ | |a Sams, Mikko |0 P:(DE-HGF)0 |b 8 |
| 700 | 1 | _ | |a Raij, Tuukka T. |0 P:(DE-HGF)0 |b 9 |e Corresponding author |
| 773 | _ | _ | |a 10.1016/j.bpsc.2023.06.002 |g Vol. 8, no. 12, p. 1197 - 1206 |0 PERI:(DE-600)2879089-3 |n 12 |p 1197 - 1206 |t Biological psychiatry / Cognitive neuroscience and neuroimaging |v 8 |y 2023 |x 2451-9022 |
| 856 | 4 | _ | |u https://doi.org/10.1016/j.bpsc.2023.06.002 |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/1019154/files/1-s2.0-S2451902223001453-main.pdf |y OpenAccess |
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