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@ARTICLE{Kamierowska:1019359,
      author       = {Kaźmierowska, Anna M. and Kostecki, Mateusz and
                      Szczepanik, Michał and Nikolaev, Tomasz and Hamed, Adam and
                      Michałowski, Jarosław M. and Wypych, Marek and Marchewka,
                      Artur and Knapska, Ewelina},
      title        = {{R}ats respond to aversive emotional arousal of human
                      handlers with the activation of the basolateral and central
                      amygdala},
      journal      = {Proceedings of the National Academy of Sciences of the
                      United States of America},
      volume       = {120},
      number       = {46},
      issn         = {0027-8424},
      address      = {Washington, DC},
      publisher    = {National Acad. of Sciences},
      reportid     = {FZJ-2023-05329},
      pages        = {e2302655120},
      year         = {2023},
      note         = {Data collection and analysis were sponsored by the National
                      Science Centre (Poland) grant 2015/19/B/HS6/02209. Ewelina
                      Knapska was supported by the European Research Council
                      Starting Grant (H 415148).},
      abstract     = {Reading danger signals may save an animal’s life, and
                      learning about threats from others allows avoiding
                      first-hand aversive and often fatal experiences. Fear
                      expressed by other individuals, including those belonging to
                      other species, may indicate the presence of a threat in the
                      environment and is an important social cue. Humans and other
                      animals respond to conspecifics’ fear with increased
                      activity of the amygdala, the brain structure crucial for
                      detecting threats and mounting an appropriate response to
                      them. It is unclear, however, whether the cross-species
                      transmission of threat information involves similar
                      mechanisms, e.g., whether animals respond to the aversively
                      induced emotional arousal of humans with activation of
                      fear-processing circuits in the brain. Here, we report that
                      when rats interact with a human caregiver who had recently
                      undergone fear conditioning, they show risk assessment
                      behavior and enhanced amygdala activation. The amygdala
                      response involves its two major parts, the basolateral and
                      central, which detect a threat and orchestrate defensive
                      responses. Further, we show that humans who learn about a
                      threat by observing another aversively aroused human,
                      similar to rats, activate the basolateral and centromedial
                      parts of the amygdala. Our results demonstrate that rats
                      detect the emotional arousal of recently aversively
                      stimulated caregivers and suggest that cross-species social
                      transmission of threat information may involve similar
                      neural circuits in the amygdala as the within-species
                      transmission.},
      cin          = {INM-7},
      ddc          = {500},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5253 - Neuroimaging (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5253},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {37934822},
      UT           = {WOS:001133694500003},
      doi          = {10.1073/pnas.2302655120},
      url          = {https://juser.fz-juelich.de/record/1019359},
}