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@ARTICLE{Saberi:1019709,
      author       = {Saberi, Amin and Ebneabbasi, Amir and Rahimi, Sama and
                      Sarebannejad, Sara and Sen, Zumrut Duygu and Graf, Heiko and
                      Walter, Martin and Sorg, Christian and Camilleri, Julia and
                      Laird, Angela R. and Fox, Peter T. and Valk, Sofie L. and
                      Eickhoff, Simon B. and Tahmasian, Masoud},
      title        = {{C}onvergent functional effects of antidepressants in major
                      depressive disorder: a neuroimaging meta-analysis},
      reportid     = {FZJ-2023-05563},
      year         = {2023},
      note         = {AS and SLV were funded by the Max Planck Society (Otto Hahn
                      award) and Helmholtz Association’s Initiative and
                      Networking Fund under the Helmholtz International Lab grant
                      agreement InterLabs-0015, and the Canada First Research
                      Excellence Fund (CFREF Competition 2, 2015–2016) awarded
                      to the Healthy Brains, Healthy Lives initiative at McGill
                      University, through the Helmholtz International BigBrain
                      Analytics and Learning Laboratory (HIBALL). SBE was
                      supported by the Deutsche Forschungsgemeinschaft (DFG, EI
                      816/21-1), the National Institute of Mental Health
                      (R01-MH074457), and the European Union’s Horizon 2020
                      Research and Innovation Programme under Grant Agreement No.
                      945539 (HBP SGA3).},
      abstract     = {Background: Neuroimaging studies have provided valuable
                      insights into the macroscale impacts of antidepressants on
                      brain functions in patients with major depressive disorder.
                      However, the findings of individual studies are
                      inconsistent. Here, we aimed to provide a quantitative
                      synthesis of the literature to identify convergence of the
                      reported findings at both regional and network levels and to
                      examine their associations with neurotransmitter
                      systems.Methods: Through a comprehensive search in PubMed
                      and Scopus databases, we reviewed 5,258 abstracts and
                      identified 37 eligible functional neuroimaging studies on
                      antidepressant effects in major depressive disorder.
                      Activation likelihood estimation was used to investigate
                      regional convergence of the reported foci of consistent
                      antidepressant effects, followed by functional decoding and
                      connectivity mapping of the convergent clusters.
                      Additionally, utilizing group-averaged data from the Human
                      Connectome Project, we assessed convergent resting-state
                      functional connectivity patterns of the reported foci. Next,
                      we compared the convergent circuit with the circuits
                      targeted by transcranial magnetic stimulation (TMS) therapy.
                      Last, we studied the association of regional and
                      network-level convergence maps with the selected
                      neurotransmitter receptors/transporters maps.Results: We
                      found regional convergence of the reported
                      treatment-associated increases of functional measures in the
                      left dorsolateral prefrontal cortex, which was associated
                      with working memory and attention behavioral domains. No
                      regional convergence was found across foci of alterations in
                      functional imaging associated with antidepressants.
                      Moreover, we found network-level convergence of functional
                      alterations in a circuit that was prominent in the
                      frontoparietal and salience networks. This circuit was
                      co-aligned with a circuit targeted by anti-subgenual TMS
                      therapy. We observed no significant correlations between our
                      meta-analytic findings with the maps of neurotransmitter
                      receptors/transporters.Conclusion: Our findings highlight
                      the importance of the left dorsolateral prefrontal cortex,
                      as well as frontoparietal network and the salience network
                      in the therapeutic effects of anti-depressants, possibly
                      associated with their role in improving executive functions
                      and emotional processing.},
      cin          = {INM-7},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5253 - Neuroimaging (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5253},
      typ          = {PUB:(DE-HGF)25},
      doi          = {10.1101/2023.11.24.23298991},
      url          = {https://juser.fz-juelich.de/record/1019709},
}