001019880 001__ 1019880
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001019880 037__ $$aFZJ-2023-05706
001019880 041__ $$aEnglish
001019880 1001_ $$0P:(DE-Juel1)130749$$aKang, Kyongok$$b0$$eCorresponding author
001019880 1112_ $$aDuesseldorf-Juelich Symposium on Neurodegenerative Diseases$$cDuesseldorf$$d2023-12-05 - 2023-12-07$$wGermany
001019880 245__ $$aElectric‑field induced modulation of amorphous protein-salt aggregates and phase behavior
001019880 260__ $$c2023
001019880 3367_ $$033$$2EndNote$$aConference Paper
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001019880 520__ $$aProteins in their native state are marginally stable and tend to aggregate. Controlling protein aggregation is very important, but still a major challenge in various fields, including medicine, pharmacology, food processing, and materials science.  The flexible, amorphous, micron-sized protein aggregates composed of lysozyme molecules reduced by dithiothreitol are used for a model system that are exposed to a weak alternating current electric field. Their field response is followed an in situ  by time-resolved polarized optical microscopy, revealing field-induced deformation, reorientation and enhanced polarization as well as the disintegration of large clusters of aggregates [1]. Also, the lysozyme crystal in salt solutions are investigated by the phase diagram in the presence of electric fields [2], underlying the gas-liquid and liquid-liquid phase separation in the early stage of protein aggregates.  In addition, the effects of fatty acid, ionic strength, and the weak AC electric field in basic  functional protein BSA solutions [3],  are explored by the collective microscopic dynamics of interacting protein aggregates.  These protein aggregates in the phase behavior are then fundamentally interesting in the driving formation of microscopic elongation of anisotropic growth. [1] Kyongok Kang and Florian Platten, “Electric‑field induced modulation of amorphous protein aggregates: polarization, deformation, and reorientation”,      Scientific Reports 12:3061 (2022).[2] D. Ray, K. Kang, and F. Platten et al, “Lysozyme-salt protein aggregates in electric-fields”, in preparation (2023).[3] Kyongok Kang, “The effect of fatty acids, ionic strength, and electric fields on the microscopic dynamics of BSA aggregates,       Frontiers in Physics 11:1282099 (2023)
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001019880 9141_ $$y2023
001019880 920__ $$lyes
001019880 9201_ $$0I:(DE-Juel1)IBI-4-20200312$$kIBI-4$$lBiomakromolekulare Systeme und Prozesse$$x0
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