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@INPROCEEDINGS{Kang:1019880,
      author       = {Kang, Kyongok},
      title        = {{E}lectric‑field induced modulation of amorphous
                      protein-salt aggregates and phase behavior},
      reportid     = {FZJ-2023-05706},
      year         = {2023},
      abstract     = {Proteins in their native state are marginally stable and
                      tend to aggregate. Controlling protein aggregation is very
                      important, but still a major challenge in various fields,
                      including medicine, pharmacology, food processing, and
                      materials science. The flexible, amorphous, micron-sized
                      protein aggregates composed of lysozyme molecules reduced by
                      dithiothreitol are used for a model system that are exposed
                      to a weak alternating current electric field. Their field
                      response is followed an in situ by time-resolved polarized
                      optical microscopy, revealing field-induced deformation,
                      reorientation and enhanced polarization as well as the
                      disintegration of large clusters of aggregates [1]. Also,
                      the lysozyme crystal in salt solutions are investigated by
                      the phase diagram in the presence of electric fields [2],
                      underlying the gas-liquid and liquid-liquid phase separation
                      in the early stage of protein aggregates. In addition, the
                      effects of fatty acid, ionic strength, and the weak AC
                      electric field in basic functional protein BSA solutions
                      [3], are explored by the collective microscopic dynamics of
                      interacting protein aggregates. These protein aggregates in
                      the phase behavior are then fundamentally interesting in the
                      driving formation of microscopic elongation of anisotropic
                      growth. [1] Kyongok Kang and Florian Platten,
                      “Electric‑field induced modulation of amorphous protein
                      aggregates: polarization, deformation, and reorientation”,
                      Scientific Reports 12:3061 (2022).[2] D. Ray, K. Kang, and
                      F. Platten et al, “Lysozyme-salt protein aggregates in
                      electric-fields”, in preparation (2023).[3] Kyongok Kang,
                      “The effect of fatty acids, ionic strength, and electric
                      fields on the microscopic dynamics of BSA aggregates,
                      Frontiers in Physics 11:1282099 (2023)},
      month         = {Dec},
      date          = {2023-12-05},
      organization  = {Duesseldorf-Juelich Symposium on
                       Neurodegenerative Diseases, Duesseldorf
                       (Germany), 5 Dec 2023 - 7 Dec 2023},
      subtyp        = {Other},
      cin          = {IBI-4},
      cid          = {I:(DE-Juel1)IBI-4-20200312},
      pnm          = {5241 - Molecular Information Processing in Cellular Systems
                      (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5241},
      typ          = {PUB:(DE-HGF)24},
      url          = {https://juser.fz-juelich.de/record/1019880},
}