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001021145 037__ $$aFZJ-2024-00599
001021145 1001_ $$0P:(DE-Juel1)136837$$aFahlke, Christoph$$b0$$eEditor$$ufzj
001021145 245__ $$aFluoride Transport and Inhibition Across CLC Transporters
001021145 260__ $$aCham$$bSpringer International Publishing$$c2024
001021145 29510 $$aAnion Channels and Transporters / Fahlke, Christoph (Editor) ; Cham : Springer International Publishing, 2024, Chapter 593 ; ISSN: 0171-2004=1865-0325 ; ISBN: 978-3-031-51345-9=978-3-031-51346-6 ; doi:10.1007/978-3-031-51346-6
001021145 300__ $$a81 - 100
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001021145 4900_ $$aHandbook of Experimental Pharmacology$$v283
001021145 520__ $$aThe Chloride Channel (CLC) family includes proton-coupled chloride and fluoride transporters. Despite their similar protein architecture, the former exchange two chloride ions for each proton and are inhibited by fluoride, whereas the latter efficiently transport one fluoride in exchange for one proton. The combination of structural, mutagenesis, and functional experiments with molecular simulations has pinpointed several amino acid changes in the permeation pathway that capitalize on the different chemical properties of chloride and fluoride to fine-tune protein function. Here we summarize recent findings on fluoride inhibition and transport in the two prototypical members of the CLC family, the chloride/proton transporter from Escherichia coli (CLC-ec1) and the fluoride/proton transporter from Enterococcus casseliflavus (CLCF-eca).
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001021145 536__ $$0G:(GEPRIS)329460521$$aDFG project 329460521 - Protonentransfer und Substraterkennung in SLC17-Transportern (329460521)$$c329460521$$x2
001021145 536__ $$0G:(GEPRIS)368482240$$aGRK 2416 - GRK 2416: MultiSenses-MultiScales: Neue Ansätze zur Aufklärung neuronaler multisensorischer Integration (368482240)$$c368482240$$x3
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001021145 7001_ $$0P:(DE-Juel1)178682$$aAsgharpour, Somayeh$$b1
001021145 7001_ $$0P:(DE-HGF)0$$aChi, L. América$$b2
001021145 7001_ $$0P:(DE-HGF)0$$aSpehr, Marc$$b3
001021145 7001_ $$0P:(DE-Juel1)145614$$aCarloni, Paolo$$b4$$eCorresponding author$$ufzj
001021145 7001_ $$0P:(DE-Juel1)169976$$aAlfonso-Prieto, Mercedes$$b5$$eCorresponding author$$ufzj
001021145 773__ $$a10.1007/164_2022_593
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