TY  - CHAP
AU  - Asgharpour, Somayeh
AU  - Chi, L. América
AU  - Spehr, Marc
AU  - Carloni, Paolo
AU  - Alfonso-Prieto, Mercedes
A3  - Fahlke, Christoph
TI  - Fluoride Transport and Inhibition Across CLC Transporters
VL  - 283
CY  - Cham
PB  - Springer International Publishing
M1  - FZJ-2024-00599
SN  - 978-3-031-51346-6
T2  - Handbook of Experimental Pharmacology
SP  - 81 - 100
PY  - 2024
AB  - The Chloride Channel (CLC) family includes proton-coupled chloride and fluoride transporters. Despite their similar protein architecture, the former exchange two chloride ions for each proton and are inhibited by fluoride, whereas the latter efficiently transport one fluoride in exchange for one proton. The combination of structural, mutagenesis, and functional experiments with molecular simulations has pinpointed several amino acid changes in the permeation pathway that capitalize on the different chemical properties of chloride and fluoride to fine-tune protein function. Here we summarize recent findings on fluoride inhibition and transport in the two prototypical members of the CLC family, the chloride/proton transporter from Escherichia coli (CLC-ec1) and the fluoride/proton transporter from Enterococcus casseliflavus (CLCF-eca).
LB  - PUB:(DE-HGF)7
C6  - 36042142
UR  - <Go to ISI:>//WOS:001283285500005
DO  - DOI:10.1007/164_2022_593
UR  - https://juser.fz-juelich.de/record/1021145
ER  -