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@INBOOK{Fahlke:1021145,
      author       = {Asgharpour, Somayeh and Chi, L. América and Spehr, Marc
                      and Carloni, Paolo and Alfonso-Prieto, Mercedes},
      editor       = {Fahlke, Christoph},
      title        = {{F}luoride {T}ransport and {I}nhibition {A}cross {CLC}
                      {T}ransporters},
      volume       = {283},
      address      = {Cham},
      publisher    = {Springer International Publishing},
      reportid     = {FZJ-2024-00599},
      isbn         = {978-3-031-51346-6},
      series       = {Handbook of Experimental Pharmacology},
      pages        = {81 - 100},
      year         = {2024},
      comment      = {Anion Channels and Transporters / Fahlke, Christoph
                      (Editor) ; Cham : Springer International Publishing, 2024,
                      Chapter 593 ; ISSN: 0171-2004=1865-0325 ; ISBN:
                      978-3-031-51345-9=978-3-031-51346-6 ;
                      doi:10.1007/978-3-031-51346-6},
      booktitle     = {Anion Channels and Transporters /
                       Fahlke, Christoph (Editor) ; Cham :
                       Springer International Publishing,
                       2024, Chapter 593 ; ISSN:
                       0171-2004=1865-0325 ; ISBN:
                       978-3-031-51345-9=978-3-031-51346-6 ;
                       doi:10.1007/978-3-031-51346-6},
      abstract     = {The Chloride Channel (CLC) family includes proton-coupled
                      chloride and fluoride transporters. Despite their similar
                      protein architecture, the former exchange two chloride ions
                      for each proton and are inhibited by fluoride, whereas the
                      latter efficiently transport one fluoride in exchange for
                      one proton. The combination of structural, mutagenesis, and
                      functional experiments with molecular simulations has
                      pinpointed several amino acid changes in the permeation
                      pathway that capitalize on the different chemical properties
                      of chloride and fluoride to fine-tune protein function. Here
                      we summarize recent findings on fluoride inhibition and
                      transport in the two prototypical members of the CLC family,
                      the chloride/proton transporter from Escherichia coli
                      (CLC-ec1) and the fluoride/proton transporter from
                      Enterococcus casseliflavus (CLCF-eca).},
      cin          = {IAS-5 / INM-9},
      cid          = {I:(DE-Juel1)IAS-5-20120330 / I:(DE-Juel1)INM-9-20140121},
      pnm          = {5241 - Molecular Information Processing in Cellular Systems
                      (POF4-524) / DFG project 291198853 - FOR 2518: Funktionale
                      Dynamik von Ionenkanälen und Transportern - DynIon -
                      (291198853) / DFG project 329460521 - Protonentransfer und
                      Substraterkennung in SLC17-Transportern (329460521) / GRK
                      2416 - GRK 2416: MultiSenses-MultiScales: Neue Ansätze zur
                      Aufklärung neuronaler multisensorischer Integration
                      (368482240)},
      pid          = {G:(DE-HGF)POF4-5241 / G:(GEPRIS)291198853 /
                      G:(GEPRIS)329460521 / G:(GEPRIS)368482240},
      typ          = {PUB:(DE-HGF)7},
      pubmed       = {36042142},
      UT           = {WOS:001283285500005},
      doi          = {10.1007/164_2022_593},
      url          = {https://juser.fz-juelich.de/record/1021145},
}