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| Hauptseite > Publikationsdatenbank > Fluoride Transport and Inhibition Across CLC Transporters > print |
| Hauptseite > Publikationsdatenbank > Fluoride Transport and Inhibition Across CLC Transporters > print |
| 001 | 1021145 | ||
| 005 | 20241023094530.0 | ||
| 020 | _ | _ | |a 978-3-031-51346-6 |
| 020 | _ | _ | |a 978-3-031-51346-6 (electronic) |
| 024 | 7 | _ | |a 10.1007/164_2022_593 |2 doi |
| 024 | 7 | _ | |a 36042142 |2 pmid |
| 024 | 7 | _ | |a WOS:001283285500005 |2 WOS |
| 037 | _ | _ | |a FZJ-2024-00599 |
| 100 | 1 | _ | |a Fahlke, Christoph |0 P:(DE-Juel1)136837 |b 0 |e Editor |u fzj |
| 245 | _ | _ | |a Fluoride Transport and Inhibition Across CLC Transporters |
| 260 | _ | _ | |a Cham |c 2024 |b Springer International Publishing |
| 295 | 1 | 0 | |a Anion Channels and Transporters / Fahlke, Christoph (Editor) ; Cham : Springer International Publishing, 2024, Chapter 593 ; ISSN: 0171-2004=1865-0325 ; ISBN: 978-3-031-51345-9=978-3-031-51346-6 ; doi:10.1007/978-3-031-51346-6 |
| 300 | _ | _ | |a 81 - 100 |
| 336 | 7 | _ | |a BOOK_CHAPTER |2 ORCID |
| 336 | 7 | _ | |a Book Section |0 7 |2 EndNote |
| 336 | 7 | _ | |a bookPart |2 DRIVER |
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| 490 | 0 | _ | |a Handbook of Experimental Pharmacology |v 283 |
| 520 | _ | _ | |a The Chloride Channel (CLC) family includes proton-coupled chloride and fluoride transporters. Despite their similar protein architecture, the former exchange two chloride ions for each proton and are inhibited by fluoride, whereas the latter efficiently transport one fluoride in exchange for one proton. The combination of structural, mutagenesis, and functional experiments with molecular simulations has pinpointed several amino acid changes in the permeation pathway that capitalize on the different chemical properties of chloride and fluoride to fine-tune protein function. Here we summarize recent findings on fluoride inhibition and transport in the two prototypical members of the CLC family, the chloride/proton transporter from Escherichia coli (CLC-ec1) and the fluoride/proton transporter from Enterococcus casseliflavus (CLCF-eca). |
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| 536 | _ | _ | |a DFG project 291198853 - FOR 2518: Funktionale Dynamik von Ionenkanälen und Transportern - DynIon - (291198853) |0 G:(GEPRIS)291198853 |c 291198853 |x 1 |
| 536 | _ | _ | |a DFG project 329460521 - Protonentransfer und Substraterkennung in SLC17-Transportern (329460521) |0 G:(GEPRIS)329460521 |c 329460521 |x 2 |
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| 700 | 1 | _ | |a Asgharpour, Somayeh |0 P:(DE-Juel1)178682 |b 1 |
| 700 | 1 | _ | |a Chi, L. América |0 P:(DE-HGF)0 |b 2 |
| 700 | 1 | _ | |a Spehr, Marc |0 P:(DE-HGF)0 |b 3 |
| 700 | 1 | _ | |a Carloni, Paolo |0 P:(DE-Juel1)145614 |b 4 |e Corresponding author |u fzj |
| 700 | 1 | _ | |a Alfonso-Prieto, Mercedes |0 P:(DE-Juel1)169976 |b 5 |e Corresponding author |u fzj |
| 773 | _ | _ | |a 10.1007/164_2022_593 |
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