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@ARTICLE{Strecker:1021171,
      author       = {Strecker, J. and Wachten, T. and Neumaier, B. and Spahn,
                      I.},
      title        = {{R}adiochemical isolation of 45{T}i using ion
                      chromatography},
      journal      = {Journal of radioanalytical and nuclear chemistry},
      volume       = {333},
      issn         = {0022-4081},
      address      = {Dordrecht [u.a.]},
      publisher    = {Springer Science + Business Media B.V.},
      reportid     = {FZJ-2024-00617},
      pages        = {3631–3637},
      year         = {2024},
      abstract     = {45Ti exhibits favorable decay properties for positron
                      emission tomography (PET) imaging and can be easily produced
                      bythe bombardment of natural scandium (Sc) by protons using
                      the 45Sc(p,n)45Ti nuclear reaction. However, separation
                      of45Ti from irradiated Sc targets is arduous due to the
                      hydrolytic instability of Ti(IV) complexes, making it a
                      significant bottleneckfor routine application of this
                      radionuclide. In the present work, we describe the
                      development and optimization ofan ion chromatographic
                      separation method based on trapping of 45Ti on a
                      hydroxamate-functionalized chelating resin andsubsequent
                      elution with oxalic acid at pH = 2.8. Under optimized
                      conditions, this method enabled 45Ti-recovery of 61 ±
                      $8\%within$ 7 min. Sc contamination in scaled-up experiments
                      was found to be only 3.0 ± 1.8 μg/mL. The resulting
                      45Ti-solutionwas directly used for complexation with CDTA as
                      a model chelator, affording the corresponding [45Ti]Ti(cdta)
                      complex witha radiochemical conversion of 73 ± $3\%.$
                      Conclusively, this promising method could be transferred to
                      automated synthesismodules and should enable the preparation
                      of 45Ti-labeled compounds for PET imaging.},
      cin          = {INM-5},
      ddc          = {540},
      cid          = {I:(DE-Juel1)INM-5-20090406},
      pnm          = {5253 - Neuroimaging (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5253},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:001136343800005},
      doi          = {10.1007/s10967-023-09270-z},
      url          = {https://juser.fz-juelich.de/record/1021171},
}