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001     1021171
005     20250204113751.0
024 7 _ |a 10.1007/s10967-023-09270-z
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024 7 _ |a 0236-5731
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024 7 _ |a 0134-0719
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024 7 _ |a 1417-2097
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024 7 _ |a 1588-2780
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024 7 _ |a 2064-2857
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024 7 _ |a 10.34734/FZJ-2024-00617
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100 1 _ |a Strecker, J.
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245 _ _ |a Radiochemical isolation of 45Ti using ion chromatography
260 _ _ |a Dordrecht [u.a.]
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520 _ _ |a 45Ti exhibits favorable decay properties for positron emission tomography (PET) imaging and can be easily produced bythe bombardment of natural scandium (Sc) by protons using the 45Sc(p,n)45Ti nuclear reaction. However, separation of45Ti from irradiated Sc targets is arduous due to the hydrolytic instability of Ti(IV) complexes, making it a significant bottleneckfor routine application of this radionuclide. In the present work, we describe the development and optimization ofan ion chromatographic separation method based on trapping of 45Ti on a hydroxamate-functionalized chelating resin andsubsequent elution with oxalic acid at pH = 2.8. Under optimized conditions, this method enabled 45Ti-recovery of 61 ± 8%within 7 min. Sc contamination in scaled-up experiments was found to be only 3.0 ± 1.8 μg/mL. The resulting 45Ti-solutionwas directly used for complexation with CDTA as a model chelator, affording the corresponding [45Ti]Ti(cdta) complex witha radiochemical conversion of 73 ± 3%. Conclusively, this promising method could be transferred to automated synthesismodules and should enable the preparation of 45Ti-labeled compounds for PET imaging.
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700 1 _ |a Wachten, T.
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700 1 _ |a Neumaier, B.
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700 1 _ |a Spahn, I.
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773 _ _ |a 10.1007/s10967-023-09270-z
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