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001021438 1001_ $$0P:(DE-Juel1)179561$$aEberle, Raphael Josef$$b0$$eCorresponding author
001021438 245__ $$aTau protein aggregation associated with SARS-CoV-2 main protease
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001021438 520__ $$aThe primary function of virus proteases is the proteolytic processing of the viral polyprotein. These enzymes can also cleave host cell proteins, which is important for viral pathogenicity, modulation of cellular processes, viral replication, the defeat of antiviral responses and modulation of the immune response. It is known that COVID-19 can influence multiple tissues or organs and that infection can damage the functionality of the brain in multiple ways. After COVID-19 infections, amyloid-β, neurogranin, tau and phosphorylated tau were detected extracellularly, implicating possible neurodegenerative processes. The present study describes the possible induction of tau aggregation by the SARS-CoV-2 3CL protease (3CLpro) possibly relevant in neuropathology. Further investigations demonstrated that tau was proteolytically cleaved by the viral protease 3CL and, consequently, generated aggregates. However, more evidence is needed to confirm that COVID-19 is able to trigger neurodegenerative diseases.
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001021438 7001_ $$0P:(DE-Juel1)180738$$aCoronado, Mônika Aparecida$$b1
001021438 7001_ $$0P:(DE-Juel1)171922$$aGering, Ian$$b2
001021438 7001_ $$0P:(DE-Juel1)186754$$aSommerhage, Simon$$b3$$ufzj
001021438 7001_ $$0P:(DE-Juel1)179345$$aKorostov, Karolina$$b4$$ufzj
001021438 7001_ $$00000-0001-8532-954X$$aStefanski, Anja$$b5
001021438 7001_ $$00000-0002-3111-9368$$aStühler, Kai$$b6
001021438 7001_ $$0P:(DE-Juel1)172001$$aKraemer-Schulien, Victoria$$b7
001021438 7001_ $$0P:(DE-Juel1)177730$$aBlömeke, Lara$$b8
001021438 7001_ $$0P:(DE-Juel1)157832$$aBannach, Oliver$$b9
001021438 7001_ $$0P:(DE-Juel1)132029$$aWillbold, Dieter$$b10
001021438 773__ $$0PERI:(DE-600)2267670-3$$a10.1371/journal.pone.0288138$$gVol. 18, no. 8, p. e0288138 -$$n8$$pe0288138 -$$tPLOS ONE$$v18$$x1932-6203$$y2023
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