TY  - JOUR
AU  - Eberle, Raphael Josef
AU  - Coronado, Mônika Aparecida
AU  - Gering, Ian
AU  - Sommerhage, Simon
AU  - Korostov, Karolina
AU  - Stefanski, Anja
AU  - Stühler, Kai
AU  - Kraemer-Schulien, Victoria
AU  - Blömeke, Lara
AU  - Bannach, Oliver
AU  - Willbold, Dieter
TI  - Tau protein aggregation associated with SARS-CoV-2 main protease
JO  - PLOS ONE
VL  - 18
IS  - 8
SN  - 1932-6203
CY  - San Francisco, California, US
PB  - PLOS
M1  - FZJ-2024-00734
SP  - e0288138 -
PY  - 2023
AB  - The primary function of virus proteases is the proteolytic processing of the viral polyprotein. These enzymes can also cleave host cell proteins, which is important for viral pathogenicity, modulation of cellular processes, viral replication, the defeat of antiviral responses and modulation of the immune response. It is known that COVID-19 can influence multiple tissues or organs and that infection can damage the functionality of the brain in multiple ways. After COVID-19 infections, amyloid-β, neurogranin, tau and phosphorylated tau were detected extracellularly, implicating possible neurodegenerative processes. The present study describes the possible induction of tau aggregation by the SARS-CoV-2 3CL protease (3CLpro) possibly relevant in neuropathology. Further investigations demonstrated that tau was proteolytically cleaved by the viral protease 3CL and, consequently, generated aggregates. However, more evidence is needed to confirm that COVID-19 is able to trigger neurodegenerative diseases.
LB  - PUB:(DE-HGF)16
DO  - DOI:10.1371/journal.pone.0288138
UR  - https://juser.fz-juelich.de/record/1021438
ER  -