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@ARTICLE{Eberle:1021438,
      author       = {Eberle, Raphael Josef and Coronado, Mônika Aparecida and
                      Gering, Ian and Sommerhage, Simon and Korostov, Karolina and
                      Stefanski, Anja and Stühler, Kai and Kraemer-Schulien,
                      Victoria and Blömeke, Lara and Bannach, Oliver and
                      Willbold, Dieter},
      title        = {{T}au protein aggregation associated with {SARS}-{C}o{V}-2
                      main protease},
      journal      = {PLOS ONE},
      volume       = {18},
      number       = {8},
      issn         = {1932-6203},
      address      = {San Francisco, California, US},
      publisher    = {PLOS},
      reportid     = {FZJ-2024-00734},
      pages        = {e0288138 -},
      year         = {2023},
      abstract     = {The primary function of virus proteases is the proteolytic
                      processing of the viral polyprotein. These enzymes can also
                      cleave host cell proteins, which is important for viral
                      pathogenicity, modulation of cellular processes, viral
                      replication, the defeat of antiviral responses and
                      modulation of the immune response. It is known that COVID-19
                      can influence multiple tissues or organs and that infection
                      can damage the functionality of the brain in multiple ways.
                      After COVID-19 infections, amyloid-β, neurogranin, tau and
                      phosphorylated tau were detected extracellularly,
                      implicating possible neurodegenerative processes. The
                      present study describes the possible induction of tau
                      aggregation by the SARS-CoV-2 3CL protease (3CLpro) possibly
                      relevant in neuropathology. Further investigations
                      demonstrated that tau was proteolytically cleaved by the
                      viral protease 3CL and, consequently, generated aggregates.
                      However, more evidence is needed to confirm that COVID-19 is
                      able to trigger neurodegenerative diseases.},
      cin          = {IBI-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)IBI-7-20200312},
      pnm          = {5244 - Information Processing in Neuronal Networks
                      (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5244},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1371/journal.pone.0288138},
      url          = {https://juser.fz-juelich.de/record/1021438},
}