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@ARTICLE{Pils:1021439,
      author       = {Pils, Marlene and Rutsch, Julia and Eren, Feride and
                      Engberg, Göran and Piehl, Fredrik and Cervenka, Simon and
                      Sellgren, Carl and Troßbach, Svenja and Willbold, Dieter
                      and Erhardt, Sophie and Bannach, Oliver and Korth, Carsten},
      title        = {{D}isrupted‐in‐schizophrenia 1 protein aggregates in
                      cerebrospinal fluid are elevated in patients with
                      first‐episode psychosis},
      journal      = {Psychiatry and clinical neurosciences},
      volume       = {77},
      number       = {12},
      issn         = {1323-1316},
      address      = {Oxford [u.a.]},
      publisher    = {Wiley-Blackwell},
      reportid     = {FZJ-2024-00735},
      pages        = {665 - 671},
      year         = {2023},
      abstract     = {Aim: The disrupted-in-schizophrenia 1 (DISC1) protein is a
                      key regulator at the intersection of major signaling
                      pathways relevant for adaptive behavior. It is prone to
                      posttranslational changes such as misassembly and
                      aggregation but the significance of such transformations for
                      human mental illness has remained unclear. We aimed to
                      demonstrate the occurrence of DISC1 protein aggregates in
                      patients with first-episode psychosis (FEP).Method:
                      Cerebrospinal fluid samples of patients with FEP (n = 50)
                      and matched healthy controls (HCs; n = 47) were measured by
                      the highly sensitive surface-based fluorescence intensity
                      distribution analysis technology that enables single
                      aggregate detection.Results: We demonstrate that DISC1
                      protein aggregates are increased in cerebrospinal fluid
                      samples of patients with FEP versus HCs. The concentration
                      was in the low femtomolar range. No correlations were found
                      with specific symptom levels, but the difference was
                      particularly significant in the subset of patients with the
                      diagnoses schizophrenia, unspecified (DSM-IV 295.9) or
                      schizoaffective disorder (DSM-IV 295.70) at 18-month
                      follow-up. DISC1 protein aggregate levels did not
                      significantly change within the 18-month observation
                      interval and were on average higher for individuals carrying
                      the major DISC1 rs821577 allele, before
                      correction.Conclusion: The occurrence of protein aggregates
                      in vivo in patients with psychotic disorders has not been
                      previously reported. It underscores the significance of
                      posttranslational modifications of proteins both as
                      pathogenetic mechanisms and as potential diagnostic markers
                      in these disorders.},
      cin          = {IBI-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)IBI-7-20200312},
      pnm          = {5244 - Information Processing in Neuronal Networks
                      (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5244},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {37668563},
      UT           = {WOS:001119341300001},
      doi          = {10.1111/pcn.13594},
      url          = {https://juser.fz-juelich.de/record/1021439},
}