guest ::
| Home > Publications database > Structural Impact of N‐terminal Pyroglutamylate in an Amyloid‐β(3‐42) Fibril Probed by Solid‐State NMR Spectroscopy > print |
| Home > Publications database > Structural Impact of N‐terminal Pyroglutamylate in an Amyloid‐β(3‐42) Fibril Probed by Solid‐State NMR Spectroscopy > print |
| 001 | 1021672 | ||
| 005 | 20250204113756.0 | ||
| 024 | 7 | _ | |a 10.1002/chem.202303007 |2 doi |
| 024 | 7 | _ | |a 0947-6539 |2 ISSN |
| 024 | 7 | _ | |a 1521-3765 |2 ISSN |
| 024 | 7 | _ | |a 10.34734/FZJ-2024-00927 |2 datacite_doi |
| 024 | 7 | _ | |a WOS:001138572000001 |2 WOS |
| 037 | _ | _ | |a FZJ-2024-00927 |
| 082 | _ | _ | |a 540 |
| 100 | 1 | _ | |a Gardon, Luis |0 P:(DE-Juel1)185029 |b 0 |u fzj |
| 245 | _ | _ | |a Structural Impact of N‐terminal Pyroglutamylate in an Amyloid‐β(3‐42) Fibril Probed by Solid‐State NMR Spectroscopy |
| 260 | _ | _ | |a Weinheim |c 2024 |b Wiley-VCH |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1708506917_19757 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Extracellular amyloid-β (Aβ) plaques, primarily formed by Aβ(1-40) and Aβ(1-42) fibrils, are a hallmark of Alzheimer's disease. The Aβ peptide can undergo a high variety of different post-translational modifications including formation of a pyroglutamate (pGlu, pE) at N-terminal Glu3 or Glu11 of truncated Aβ(3-x) or Aβ(11-x), respectively. Here we studied structural similarities and differences between pEAβ(3-42) and LS-shaped Aβ(1-42) fibrils grown under identical conditions (pH 2) using solid-state NMR spectroscopy. We show that the central region of pEAβ(3-42) fibrils including the turn region around V24 is almost identical to Aβ(1-42) showing similar β-strands also at the N-terminus. The missing N-terminal residues D1-A2 along with pE3 formation in pEAβ(3-42) preclude a salt bridge between K28-D1' as in Aβ(1-42) fibrils. G37 and G38 act as highly sensitive internal sensors for the modified N-terminus, which remains rigid over ~five pH units. |
| 536 | _ | _ | |a 5241 - Molecular Information Processing in Cellular Systems (POF4-524) |0 G:(DE-HGF)POF4-5241 |c POF4-524 |f POF IV |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, Journals: juser.fz-juelich.de |
| 700 | 1 | _ | |a Becker, Nina |0 P:(DE-Juel1)178027 |b 1 |
| 700 | 1 | _ | |a Gremer, Lothar |0 P:(DE-Juel1)145165 |b 2 |e Corresponding author |
| 700 | 1 | _ | |a Heise, Henrike |0 P:(DE-Juel1)132002 |b 3 |e Corresponding author |
| 773 | _ | _ | |a 10.1002/chem.202303007 |g p. e202303007 |0 PERI:(DE-600)1478547-X |n 10 |p e202303007 |t Chemistry - a European journal |v 30 |y 2024 |x 0947-6539 |
| 856 | 4 | _ | |y OpenAccess |u https://juser.fz-juelich.de/record/1021672/files/Chemistry%20A%20European%20J%20-%202023%20-%20Gardon%20-%20Structural%20Impact%20of%20N%E2%80%90terminal%20Pyroglutamate%20in%20an%20Amyloid%E2%80%90%203%E2%80%9042%20Fibril%20Probed.pdf |
| 856 | 4 | _ | |y OpenAccess |x icon |u https://juser.fz-juelich.de/record/1021672/files/Chemistry%20A%20European%20J%20-%202023%20-%20Gardon%20-%20Structural%20Impact%20of%20N%E2%80%90terminal%20Pyroglutamate%20in%20an%20Amyloid%E2%80%90%203%E2%80%9042%20Fibril%20Probed.gif?subformat=icon |
| 856 | 4 | _ | |y OpenAccess |x icon-1440 |u https://juser.fz-juelich.de/record/1021672/files/Chemistry%20A%20European%20J%20-%202023%20-%20Gardon%20-%20Structural%20Impact%20of%20N%E2%80%90terminal%20Pyroglutamate%20in%20an%20Amyloid%E2%80%90%203%E2%80%9042%20Fibril%20Probed.jpg?subformat=icon-1440 |
| 856 | 4 | _ | |y OpenAccess |x icon-180 |u https://juser.fz-juelich.de/record/1021672/files/Chemistry%20A%20European%20J%20-%202023%20-%20Gardon%20-%20Structural%20Impact%20of%20N%E2%80%90terminal%20Pyroglutamate%20in%20an%20Amyloid%E2%80%90%203%E2%80%9042%20Fibril%20Probed.jpg?subformat=icon-180 |
| 856 | 4 | _ | |y OpenAccess |x icon-640 |u https://juser.fz-juelich.de/record/1021672/files/Chemistry%20A%20European%20J%20-%202023%20-%20Gardon%20-%20Structural%20Impact%20of%20N%E2%80%90terminal%20Pyroglutamate%20in%20an%20Amyloid%E2%80%90%203%E2%80%9042%20Fibril%20Probed.jpg?subformat=icon-640 |
| 909 | C | O | |o oai:juser.fz-juelich.de:1021672 |p openaire |p open_access |p VDB |p driver |p dnbdelivery |
| 910 | 1 | _ | |a Forschungszentrum Jülich |0 I:(DE-588b)5008462-8 |k FZJ |b 0 |6 P:(DE-Juel1)185029 |
| 910 | 1 | _ | |a Forschungszentrum Jülich |0 I:(DE-588b)5008462-8 |k FZJ |b 1 |6 P:(DE-Juel1)178027 |
| 910 | 1 | _ | |a Forschungszentrum Jülich |0 I:(DE-588b)5008462-8 |k FZJ |b 2 |6 P:(DE-Juel1)145165 |
| 910 | 1 | _ | |a Forschungszentrum Jülich |0 I:(DE-588b)5008462-8 |k FZJ |b 3 |6 P:(DE-Juel1)132002 |
| 913 | 1 | _ | |a DE-HGF |b Key Technologies |l Natural, Artificial and Cognitive Information Processing |1 G:(DE-HGF)POF4-520 |0 G:(DE-HGF)POF4-524 |3 G:(DE-HGF)POF4 |2 G:(DE-HGF)POF4-500 |4 G:(DE-HGF)POF |v Molecular and Cellular Information Processing |9 G:(DE-HGF)POF4-5241 |x 0 |
| 914 | 1 | _ | |y 2024 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0160 |2 StatID |b Essential Science Indicators |d 2023-10-21 |
| 915 | _ | _ | |a Creative Commons Attribution-NonCommercial-NoDerivs CC BY-NC-ND 4.0 |0 LIC:(DE-HGF)CCBYNCND4 |2 HGFVOC |
| 915 | _ | _ | |a DEAL Wiley |0 StatID:(DE-HGF)3001 |2 StatID |d 2023-10-21 |w ger |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0113 |2 StatID |b Science Citation Index Expanded |d 2023-10-21 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1210 |2 StatID |b Index Chemicus |d 2023-10-21 |
| 915 | _ | _ | |a OpenAccess |0 StatID:(DE-HGF)0510 |2 StatID |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1200 |2 StatID |b Chemical Reactions |d 2023-10-21 |
| 915 | _ | _ | |a Nationallizenz |0 StatID:(DE-HGF)0420 |2 StatID |d 2025-01-02 |w ger |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |d 2025-01-02 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |d 2025-01-02 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |d 2025-01-02 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1150 |2 StatID |b Current Contents - Physical, Chemical and Earth Sciences |d 2025-01-02 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |d 2025-01-02 |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b CHEM-EUR J : 2022 |d 2025-01-02 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0600 |2 StatID |b Ebsco Academic Search |d 2025-01-02 |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b ASC |d 2025-01-02 |
| 915 | _ | _ | |a IF < 5 |0 StatID:(DE-HGF)9900 |2 StatID |d 2025-01-02 |
| 920 | _ | _ | |l yes |
| 920 | 1 | _ | |0 I:(DE-Juel1)IBI-7-20200312 |k IBI-7 |l Strukturbiochemie |x 0 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a UNRESTRICTED |
| 980 | _ | _ | |a I:(DE-Juel1)IBI-7-20200312 |
| 980 | 1 | _ | |a FullTexts |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|