% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Roe:1021979,
      author       = {Roe, James M and Vidal-Pineiro, Didac and Amlien, Inge K
                      and Pan, Mengyu and Sneve, Markus H and Thiebaut de
                      Schotten, Michel and Friedrich, Patrick and Sha, Zhiqiang
                      and Francks, Clyde and Eilertsen, Espen M and Wang, Yunpeng
                      and Walhovd, Kristine B and Fjell, Anders M and
                      Westerhausen, René},
      title        = {{T}racing the development and lifespan change of
                      population-level structural asymmetry in the cerebral
                      cortex},
      journal      = {eLife},
      volume       = {12},
      issn         = {2050-084X},
      address      = {Cambridge},
      publisher    = {eLife Sciences Publications},
      reportid     = {FZJ-2024-01118},
      pages        = {e84685},
      year         = {2023},
      abstract     = {Cortical asymmetry is a ubiquitous feature of brain
                      organization that is subtly altered in some
                      neurodevelopmental disorders, yet we lack knowledge of how
                      its development proceeds across life in health. Achieving
                      consensus on the precise cortical asymmetries in humans is
                      necessary to uncover the developmental timing of asymmetry
                      and the extent to which it arises through genetic and later
                      influences in childhood. Here, we delineate population-level
                      asymmetry in cortical thickness and surface area vertex-wise
                      in seven datasets and chart asymmetry trajectories
                      longitudinally across life (4–89 years; observations =
                      3937; $70\%$ longitudinal). We find replicable asymmetry
                      interrelationships, heritability maps, and test asymmetry
                      associations in large–scale data. Cortical asymmetry was
                      robust across datasets. Whereas areal asymmetry is
                      predominantly stable across life, thickness asymmetry grows
                      in childhood and peaks in early adulthood. Areal asymmetry
                      is low-moderately heritable (max h2SNP $~19\%)$ and
                      correlates phenotypically and genetically in specific
                      regions, indicating coordinated development of asymmetries
                      partly through genes. In contrast, thickness asymmetry is
                      globally interrelated across the cortex in a pattern
                      suggesting highly left-lateralized individuals tend towards
                      left-lateralization also in population-level
                      right-asymmetric regions (and vice versa), and exhibits low
                      or absent heritability. We find less areal asymmetry in the
                      most consistently lateralized region in humans associates
                      with subtly lower cognitive ability, and confirm small
                      handedness and sex effects. Results suggest areal asymmetry
                      is developmentally stable and arises early in life through
                      genetic but mainly subject-specific stochastic effects,
                      whereas childhood developmental growth shapes thickness
                      asymmetry and may lead to directional variability of global
                      thickness lateralization in the population.},
      cin          = {INM-7},
      ddc          = {600},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {37335613},
      UT           = {WOS:001070991900001},
      doi          = {10.7554/eLife.84685},
      url          = {https://juser.fz-juelich.de/record/1021979},
}