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@ARTICLE{CandiaRivera:1021983,
      author       = {Candia-Rivera, Diego and Raimondo, Federico and Pérez,
                      Pauline and Naccache, Lionel and Tallon-Baudry, Catherine
                      and Sitt, Jacobo},
      title        = {{C}onscious processing of global and local auditory
                      irregularities causes differentiated heartbeat-evoked
                      responses},
      journal      = {eLife},
      volume       = {12},
      issn         = {2050-084X},
      address      = {Cambridge},
      publisher    = {eLife Sciences Publications},
      reportid     = {FZJ-2024-01122},
      pages        = {e75352},
      year         = {2023},
      abstract     = {Recent research suggests that brain-heart interactions are
                      associated with perceptual and self-consciousness. In this
                      line, the neural responses to visceral inputs have been
                      hypothesized to play a leading role in shaping our
                      subjective experience. This study aims to investigate
                      whether the contextual processing of auditory irregularities
                      modulates both direct neuronal responses to the auditory
                      stimuli (ERPs) and the neural responses to heartbeats, as
                      measured with heartbeat-evoked responses (HERs). HERs were
                      computed in patients with disorders of consciousness,
                      diagnosed with a minimally conscious state or unresponsive
                      wakefulness syndrome. We tested whether HERs reflect
                      conscious auditory perception, which can potentially provide
                      additional information for the consciousness diagnosis. EEG
                      recordings were taken during the local-global paradigm,
                      which evaluates the capacity of a patient to detect the
                      appearance of auditory irregularities at local (short-term)
                      and global (long-term) levels. The results show that local
                      and global effects produce distinct ERPs and HERs, which can
                      help distinguish between the minimally conscious state and
                      unresponsive wakefulness syndrome patients. Furthermore, we
                      found that ERP and HER responses were not correlated
                      suggesting that independent neuronal mechanisms are behind
                      them. These findings suggest that HER modulations in
                      response to auditory irregularities, especially local
                      irregularities, may be used as a novel neural marker of
                      consciousness and may aid in the bedside diagnosis of
                      disorders of consciousness with a more cost-effective option
                      than neuroimaging methods.},
      cin          = {INM-7},
      ddc          = {600},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525) / 5252 - Brain Dysfunction and Plasticity
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251 / G:(DE-HGF)POF4-5252},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {37888955},
      UT           = {WOS:001134633800001},
      doi          = {10.7554/eLife.75352},
      url          = {https://juser.fz-juelich.de/record/1021983},
}