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@ARTICLE{Ibrahim:1021984,
      author       = {Ibrahim, Karim and Iturmendi-Sabater, Iciar and Vasishth,
                      Maya and Barron, Daniel S. and Guardavaccaro, MariaRose and
                      Funaro, Melissa C. and Holmes, Avram and McCarthy, Gregory
                      and Eickhoff, Simon B. and Sukhodolsky, Denis G.},
      title        = {{N}eural circuit disruptions of eye gaze processing in
                      autism spectrum disorder and schizophrenia: {A}n activation
                      likelihood estimation meta-analysis},
      journal      = {Schizophrenia research},
      volume       = {264},
      issn         = {0920-9964},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2024-01123},
      pages        = {298 - 313},
      year         = {2024},
      abstract     = {BackgroundImpairment in social cognition, particularly eye
                      gaze processing, is a shared feature common to autism
                      spectrum disorder (ASD) and schizophrenia. However, it is
                      unclear if a convergent neural mechanism also underlies gaze
                      dysfunction in these conditions. The present study examined
                      whether this shared eye gaze phenotype is reflected in a
                      profile of convergent neurobiological dysfunction in ASD and
                      schizophrenia.MethodsActivation likelihood estimation (ALE)
                      meta-analyses were conducted on peak voxel coordinates
                      across the whole brain to identify spatial convergence.
                      Functional coactivation with regions emerging as significant
                      was assessed using meta-analytic connectivity modeling.
                      Functional decoding was also conducted.ResultsFifty-six
                      experiments (n = 30 with schizophrenia and n = 26 with ASD)
                      from 36 articles met inclusion criteria, which comprised 354
                      participants with ASD, 275 with schizophrenia and 613
                      healthy controls (1242 participants in total). In ASD,
                      aberrant activation was found in the left amygdala relative
                      to unaffected controls during gaze processing. In
                      schizophrenia, aberrant activation was found in the right
                      inferior frontal gyrus and supplementary motor area. Across
                      ASD and schizophrenia, aberrant activation was found in the
                      right inferior frontal gyrus and right fusiform gyrus during
                      gaze processing. Functional decoding mapped the left
                      amygdala to domains related to emotion processing and
                      cognition, the right inferior frontal gyrus to cognition and
                      perception, and the right fusiform gyrus to visual
                      perception, spatial cognition, and emotion perception. These
                      regions also showed meta-analytic connectivity to
                      frontoparietal and frontotemporal
                      circuitry.ConclusionAlterations in frontoparietal and
                      frontotemporal circuitry emerged as neural markers of gaze
                      impairments in ASD and schizophrenia. These findings have
                      implications for advancing transdiagnostic biomarkers to
                      inform targeted treatments for ASD and schizophrenia.
                      Previous article in issue},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5252},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {38215566},
      UT           = {WOS:001154995000001},
      doi          = {10.1016/j.schres.2023.12.003},
      url          = {https://juser.fz-juelich.de/record/1021984},
}