TY  - JOUR
AU  - Annen, Jitka
AU  - Frasso, Gianluca
AU  - van der Lande, Glenn J. M.
AU  - Bonin, Estelle A. C.
AU  - Vitello, Marie M.
AU  - Panda, Rajanikant
AU  - Sala, Arianna
AU  - Cavaliere, Carlo
AU  - Raimondo, Federico
AU  - Bahri, Mohamed Ali
AU  - Schiff, Nicholas D.
AU  - Gosseries, Olivia
AU  - Thibaut, Aurore
AU  - Laureys, Steven
TI  - Cerebral electrometabolic coupling in disordered and normal states of consciousness
JO  - Cell reports
VL  - 42
IS  - 8
SN  - 2211-1247
CY  - [New York, NY]
PB  - Elsevier
M1  - FZJ-2024-01124
SP  - 112854 -
PY  - 2023
AB  - We assess cerebral integrity with cortical and subcortical FDG-PET and cortical electroencephalography (EEG) within the mesocircuit model framework in patients with disorders of consciousness (DoCs). The mesocircuit hypothesis proposes that subcortical activation facilitates cortical function. We find that the metabolic balance of subcortical mesocircuit areas is informative for diagnosis and is associated with four EEG-based power spectral density patterns, cortical metabolism, and α power in healthy controls and patients with a DoC. Last, regional electrometabolic coupling at the cortical level can be identified in the θ and α ranges, showing positive and negative relations with glucose uptake, respectively. This relation is inverted in patients with a DoC, potentially related to altered orchestration of neural activity, and may underlie suboptimal excitability states in patients with a DoC. By understanding the neurobiological basis of the pathophysiology underlying DoCs, we foresee translational value for diagnosis and treatment of patients with a DoC.
LB  - PUB:(DE-HGF)16
C6  - 37498745
UR  - <Go to ISI:>//WOS:001050983200001
DO  - DOI:10.1016/j.celrep.2023.112854
UR  - https://juser.fz-juelich.de/record/1021985
ER  -