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001     1021985
005     20240226075241.0
024 7 _ |a 10.1016/j.celrep.2023.112854
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024 7 _ |a 2211-1247
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024 7 _ |a 2639-1856
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024 7 _ |a 10.34734/FZJ-2024-01124
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100 1 _ |a Annen, Jitka
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245 _ _ |a Cerebral electrometabolic coupling in disordered and normal states of consciousness
260 _ _ |a [New York, NY]
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520 _ _ |a We assess cerebral integrity with cortical and subcortical FDG-PET and cortical electroencephalography (EEG) within the mesocircuit model framework in patients with disorders of consciousness (DoCs). The mesocircuit hypothesis proposes that subcortical activation facilitates cortical function. We find that the metabolic balance of subcortical mesocircuit areas is informative for diagnosis and is associated with four EEG-based power spectral density patterns, cortical metabolism, and α power in healthy controls and patients with a DoC. Last, regional electrometabolic coupling at the cortical level can be identified in the θ and α ranges, showing positive and negative relations with glucose uptake, respectively. This relation is inverted in patients with a DoC, potentially related to altered orchestration of neural activity, and may underlie suboptimal excitability states in patients with a DoC. By understanding the neurobiological basis of the pathophysiology underlying DoCs, we foresee translational value for diagnosis and treatment of patients with a DoC.
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700 1 _ |a Frasso, Gianluca
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700 1 _ |a van der Lande, Glenn J. M.
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700 1 _ |a Bonin, Estelle A. C.
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700 1 _ |a Vitello, Marie M.
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700 1 _ |a Panda, Rajanikant
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700 1 _ |a Sala, Arianna
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700 1 _ |a Cavaliere, Carlo
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700 1 _ |a Raimondo, Federico
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700 1 _ |a Bahri, Mohamed Ali
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700 1 _ |a Schiff, Nicholas D.
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700 1 _ |a Gosseries, Olivia
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700 1 _ |a Thibaut, Aurore
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700 1 _ |a Laureys, Steven
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773 _ _ |a 10.1016/j.celrep.2023.112854
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