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001     1021993
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024 7 _ |a 10.1038/s41598-023-43057-2
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100 1 _ |a Kraaijenvanger, Eline J.
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245 _ _ |a A coordinate-based meta-analysis of human amygdala connectivity alterations related to early life adversities
260 _ _ |a [London]
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520 _ _ |a 1ol.:(ͬͭͮͯͰͱͲͳʹ͵Scientific Reports | (2023) 13:16541 | https://doi.org/10.1038/s41598-023-43057-2www.nature.com/scientificreportsA coordinate‑based meta‑analysisof human amygdala connectivityalterations related to early lifeadversitiesEline J. Kraaijenvanger 1 , Tobias Banaschewski 1 , Simon B. Eickhoff 2,3 & Nathalie E. Holz 1,4,5*By affecting core neurobiological systems early in development, early life adversities (ELAs) mightconfer latent vulnerability to future psychopathologies. This coordinate‑based meta‑analysis aimsto identify significant convergent alterations in functional connectivity of the amygdala related toELAs across resting‑state and task‑based fMRI‑studies. Five electronic databases were systematicallysearched until 22 October 2020, retrieving 49 eligible studies (n = 3162 participants). Convergentalterations in functional connectivity related to ELAs between the amygdala and the anteriorcingulate cortex (ACC) and left hippocampus were found. Sub‑analyses based on hemisphere anddirection showed that connectivity seeded in the right amygdala was affected and, moreover,revealed that connectivity with ACC was decreased. Analyses based on paradigm and age showedthat amygdala‑ACC coupling was altered during resting state and that amygdala–left hippocampusconnectivity was mostly affected during task‑based paradigms and in adult participants. Whileboth regions showed altered connectivity during emotion processing and following adverse socialpostnatal experiences such as maltreatment, amygdala‑ACC coupling was mainly affected when ELAswere retrospectively assessed through self‑report. We show that ELAs are associated with alteredfunctional connectivity of the amygdala with the ACC and hippocampus. As such, ELAs may embedlatent vulnerability to future psychopathologies by systematically affecting important neurocognitivesystems.
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700 1 _ |a Banaschewski, Tobias
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700 1 _ |a Eickhoff, Simon B.
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700 1 _ |a Holz, Nathalie E.
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773 _ _ |a 10.1038/s41598-023-43057-2
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