TY  - JOUR
AU  - Javaheripour, Nooshin
AU  - Colic, Lejla
AU  - Opel, Nils
AU  - Li, Meng
AU  - Maleki Balajoo, Somayeh
AU  - Chand, Tara
AU  - Van der Meer, Johan
AU  - Krylova, Marina
AU  - Izyurov, Igor
AU  - Meller, Tina
AU  - Goltermann, Janik
AU  - Winter, Nils R.
AU  - Meinert, Susanne
AU  - Grotegerd, Dominik
AU  - Jansen, Andreas
AU  - Alexander, Nina
AU  - Usemann, Paula
AU  - Thomas-Odenthal, Florian
AU  - Evermann, Ulrika
AU  - Wroblewski, Adrian
AU  - Brosch, Katharina
AU  - Stein, Frederike
AU  - Hahn, Tim
AU  - Straube, Benjamin
AU  - Krug, Axel
AU  - Nenadić, Igor
AU  - Kircher, Tilo
AU  - Croy, Ilona
AU  - Dannlowski, Udo
AU  - Wagner, Gerd
AU  - Walter, Martin
TI  - Altered brain dynamic in major depressive disorder: state and trait features
JO  - Translational Psychiatry
VL  - 13
IS  - 1
SN  - 2158-3188
CY  - London
PB  - Nature Publishing Group
M1  - FZJ-2024-01134
SP  - 261
PY  - 2023
AB  - Temporal neural synchrony disruption can be linked to a variety of symptoms of major depressive disorder (MDD), including mood rigidity and the inability to break the cycle of negative emotion or attention biases. This might imply that altered dynamic neural synchrony may play a role in the persistence and exacerbation of MDD symptoms. Our study aimed to investigate the changes in whole-brain dynamic patterns of the brain functional connectivity and activity related to depression using the hidden Markov model (HMM) on resting-state functional magnetic resonance imaging (rs-fMRI) data. We compared the patterns of brain functional dynamics in a large sample of 314 patients with MDD (65.9% female; age (mean ± standard deviation): 35.9 ± 13.4) and 498 healthy controls (59.4% female; age: 34.0 ± 12.8). The HMM model was used to explain variations in rs-fMRI functional connectivity and averaged functional activity across the whole-brain by using a set of six unique recurring states. This study compared the proportion of time spent in each state and the average duration of visits to each state to assess stability between different groups. Compared to healthy controls, patients with MDD showed significantly higher proportional time spent and temporal stability in a state characterized by weak functional connectivity within and between all brain networks and relatively strong averaged functional activity of regions located in the somatosensory motor (SMN), salience (SN), and dorsal attention (DAN) networks. Both proportional time spent and temporal stability of this brain state was significantly associated with depression severity. Healthy controls, in contrast to the MDD group, showed proportional time spent and temporal stability in a state with relatively strong functional connectivity within and between all brain networks but weak averaged functional activity across the whole brain. These findings suggest that disrupted brain functional synchrony across time is present in MDD and associated with current depression severity.
LB  - PUB:(DE-HGF)16
C6  - 37460460
UR  - <Go to ISI:>//WOS:001033443000001
DO  - DOI:10.1038/s41398-023-02540-0
UR  - https://juser.fz-juelich.de/record/1021996
ER  -