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@ARTICLE{Javaheripour:1021996,
      author       = {Javaheripour, Nooshin and Colic, Lejla and Opel, Nils and
                      Li, Meng and Maleki Balajoo, Somayeh and Chand, Tara and Van
                      der Meer, Johan and Krylova, Marina and Izyurov, Igor and
                      Meller, Tina and Goltermann, Janik and Winter, Nils R. and
                      Meinert, Susanne and Grotegerd, Dominik and Jansen, Andreas
                      and Alexander, Nina and Usemann, Paula and Thomas-Odenthal,
                      Florian and Evermann, Ulrika and Wroblewski, Adrian and
                      Brosch, Katharina and Stein, Frederike and Hahn, Tim and
                      Straube, Benjamin and Krug, Axel and Nenadić, Igor and
                      Kircher, Tilo and Croy, Ilona and Dannlowski, Udo and
                      Wagner, Gerd and Walter, Martin},
      title        = {{A}ltered brain dynamic in major depressive disorder: state
                      and trait features},
      journal      = {Translational Psychiatry},
      volume       = {13},
      number       = {1},
      issn         = {2158-3188},
      address      = {London},
      publisher    = {Nature Publishing Group},
      reportid     = {FZJ-2024-01134},
      pages        = {261},
      year         = {2023},
      abstract     = {Temporal neural synchrony disruption can be linked to a
                      variety of symptoms of major depressive disorder (MDD),
                      including mood rigidity and the inability to break the cycle
                      of negative emotion or attention biases. This might imply
                      that altered dynamic neural synchrony may play a role in the
                      persistence and exacerbation of MDD symptoms. Our study
                      aimed to investigate the changes in whole-brain dynamic
                      patterns of the brain functional connectivity and activity
                      related to depression using the hidden Markov model (HMM) on
                      resting-state functional magnetic resonance imaging
                      (rs-fMRI) data. We compared the patterns of brain functional
                      dynamics in a large sample of 314 patients with MDD
                      $(65.9\%$ female; age (mean ± standard deviation):
                      35.9 ± 13.4) and 498 healthy controls $(59.4\%$ female;
                      age: 34.0 ± 12.8). The HMM model was used to explain
                      variations in rs-fMRI functional connectivity and averaged
                      functional activity across the whole-brain by using a set of
                      six unique recurring states. This study compared the
                      proportion of time spent in each state and the average
                      duration of visits to each state to assess stability between
                      different groups. Compared to healthy controls, patients
                      with MDD showed significantly higher proportional time spent
                      and temporal stability in a state characterized by weak
                      functional connectivity within and between all brain
                      networks and relatively strong averaged functional activity
                      of regions located in the somatosensory motor (SMN),
                      salience (SN), and dorsal attention (DAN) networks. Both
                      proportional time spent and temporal stability of this brain
                      state was significantly associated with depression severity.
                      Healthy controls, in contrast to the MDD group, showed
                      proportional time spent and temporal stability in a state
                      with relatively strong functional connectivity within and
                      between all brain networks but weak averaged functional
                      activity across the whole brain. These findings suggest that
                      disrupted brain functional synchrony across time is present
                      in MDD and associated with current depression severity.},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5252},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {37460460},
      UT           = {WOS:001033443000001},
      doi          = {10.1038/s41398-023-02540-0},
      url          = {https://juser.fz-juelich.de/record/1021996},
}