000010220 001__ 10220
000010220 005__ 20210129210518.0
000010220 0247_ $$2pmid$$apmid:20512376
000010220 0247_ $$2DOI$$a10.1007/s00429-010-0255-z
000010220 0247_ $$2WOS$$aWOS:000278898300010
000010220 0247_ $$2altmetric$$aaltmetric:3781307
000010220 037__ $$aPreJuSER-10220
000010220 041__ $$aeng
000010220 082__ $$a610
000010220 084__ $$2WoS$$aAnatomy & Morphology
000010220 084__ $$2WoS$$aNeurosciences
000010220 1001_ $$0P:(DE-Juel1)VDB67936$$aKurth, F.$$b0$$uFZJ
000010220 245__ $$aA link between the systems: functional differentiation and integration within the human insula revealed by meta-analysis
000010220 260__ $$aBerlin$$bSpringer$$c2010
000010220 300__ $$a519-534
000010220 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
000010220 3367_ $$2DataCite$$aOutput Types/Journal article
000010220 3367_ $$00$$2EndNote$$aJournal Article
000010220 3367_ $$2BibTeX$$aARTICLE
000010220 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000010220 3367_ $$2DRIVER$$aarticle
000010220 440_0 $$017221$$aBrain Structure & Function$$v214$$x1863-2653$$y5
000010220 500__ $$aThis research was funded by the National Institute of Biomedical Imaging and Bioengineering, the National Institute of Neurological Disorders and Stroke, and the National Institute of Mental Health. K.Z. acknowledges further funding by the Helmholtz Alliance "Systembiologie'' the "Human Brain Model''. A. R. L. and P. T. F. were supported by the Human Brain Project of the NIMH (R01-MH074457-01A1).
000010220 520__ $$aWhether we feel sympathy for another, listen to our heartbeat, experience pain or negotiate, the insular cortex is thought to integrate perceptions, emotions, thoughts, and plans into one subjective image of "our world". The insula has hence been ascribed an integrative role, linking information from diverse functional systems. Nevertheless, various anatomical and functional studies in humans and non-human primates also indicate a functional differentiation of this region. In order to investigate this functional differentiation as well as the mechanisms of the functional integration in the insula, we performed activation-likelihood-estimation (ALE) meta-analyses of 1,768 functional neuroimaging experiments. The analysis revealed four functionally distinct regions on the human insula, which map to the social-emotional, the sensorimotor, the olfacto-gustatory, and the cognitive network of the brain. Sensorimotor tasks activated the mid-posterior and social-emotional tasks the anterior-ventral insula. In the central insula activation by olfacto-gustatory stimuli was found, and cognitive tasks elicited activation in the anterior-dorsal region. A conjunction analysis across these domains revealed that aside from basic somatosensory and motor processes all tested functions overlapped on the anterior-dorsal insula. This overlap might constitute a correlate for a functional integration between different functional systems and thus reflect a link between them necessary to integrate different qualities into a coherent experience of the world and setting the context for thoughts and actions.
000010220 536__ $$0G:(DE-Juel1)FUEK409$$2G:(DE-HGF)$$aFunktion und Dysfunktion des Nervensystems (FUEK409)$$cFUEK409$$x0
000010220 536__ $$0G:(DE-HGF)POF2-89571$$a89571 - Connectivity and Activity (POF2-89571)$$cPOF2-89571$$fPOF II T$$x1
000010220 588__ $$aDataset connected to Web of Science, Pubmed
000010220 65320 $$2Author$$aCognitive
000010220 65320 $$2Author$$aSocial-emotional
000010220 65320 $$2Author$$aSensory
000010220 65320 $$2Author$$aBrainMap
000010220 650_2 $$2MeSH$$aAfferent Pathways: anatomy & histology
000010220 650_2 $$2MeSH$$aAfferent Pathways: physiology
000010220 650_2 $$2MeSH$$aBrain Mapping: methods
000010220 650_2 $$2MeSH$$aCerebral Cortex: anatomy & histology
000010220 650_2 $$2MeSH$$aCerebral Cortex: physiology
000010220 650_2 $$2MeSH$$aCognition: physiology
000010220 650_2 $$2MeSH$$aEmotions: physiology
000010220 650_2 $$2MeSH$$aHumans
000010220 650_2 $$2MeSH$$aModels, Neurological
000010220 650_2 $$2MeSH$$aNeural Pathways: anatomy & histology
000010220 650_2 $$2MeSH$$aNeural Pathways: physiology
000010220 650_2 $$2MeSH$$aPsychomotor Performance: physiology
000010220 650_2 $$2MeSH$$aSelf Concept
000010220 650_2 $$2MeSH$$aSmell: physiology
000010220 650_2 $$2MeSH$$aSocial Behavior
000010220 650_2 $$2MeSH$$aTaste: physiology
000010220 650_7 $$2WoSType$$aJ
000010220 7001_ $$0P:(DE-Juel1)131714$$aZilles, K.$$b1$$uFZJ
000010220 7001_ $$0P:(DE-HGF)0$$aFox, P.T.$$b2
000010220 7001_ $$0P:(DE-HGF)0$$aLaird, A.R.$$b3
000010220 7001_ $$0P:(DE-Juel1)131678$$aEickhoff, S. B.$$b4$$uFZJ
000010220 773__ $$0PERI:(DE-600)2303775-1$$a10.1007/s00429-010-0255-z$$gVol. 214$$p519-534$$q214$$tBrain structure & function$$v214$$x1863-2653$$y2010
000010220 8567_ $$uhttp://dx.doi.org/10.1007/s00429-010-0255-z
000010220 909CO $$ooai:juser.fz-juelich.de:10220$$pVDB
000010220 915__ $$0StatID:(DE-HGF)0010$$aJCR/ISI refereed
000010220 9141_ $$y2010
000010220 9132_ $$0G:(DE-HGF)POF3-571$$1G:(DE-HGF)POF3-570$$2G:(DE-HGF)POF3-500$$aDE-HGF$$bKey Technologies$$lDecoding the Human Brain$$vConnectivity and Activity$$x0
000010220 9131_ $$0G:(DE-HGF)POF2-89571$$1G:(DE-HGF)POF3-890$$2G:(DE-HGF)POF3-800$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bProgrammungebundene Forschung$$lohne Programm$$vConnectivity and Activity$$x1
000010220 9201_ $$0I:(DE-Juel1)INM-2-20090406$$gINM$$kINM-2$$lMolekulare Organisation des Gehirns$$x0
000010220 9201_ $$0I:(DE-82)080010_20140620$$gJARA$$kJARA-BRAIN$$lJülich-Aachen Research Alliance - Translational Brain Medicine$$x1
000010220 970__ $$aVDB:(DE-Juel1)120467
000010220 980__ $$aVDB
000010220 980__ $$aConvertedRecord
000010220 980__ $$ajournal
000010220 980__ $$aI:(DE-Juel1)INM-2-20090406
000010220 980__ $$aI:(DE-82)080010_20140620
000010220 980__ $$aUNRESTRICTED
000010220 981__ $$aI:(DE-Juel1)VDB1046