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@ARTICLE{Kurth:10220,
      author       = {Kurth, F. and Zilles, K. and Fox, P.T. and Laird, A.R. and
                      Eickhoff, S. B.},
      title        = {{A} link between the systems: functional differentiation
                      and integration within the human insula revealed by
                      meta-analysis},
      journal      = {Brain structure $\&$ function},
      volume       = {214},
      issn         = {1863-2653},
      address      = {Berlin},
      publisher    = {Springer},
      reportid     = {PreJuSER-10220},
      pages        = {519-534},
      year         = {2010},
      note         = {This research was funded by the National Institute of
                      Biomedical Imaging and Bioengineering, the National
                      Institute of Neurological Disorders and Stroke, and the
                      National Institute of Mental Health. K.Z. acknowledges
                      further funding by the Helmholtz Alliance "Systembiologie''
                      the "Human Brain Model''. A. R. L. and P. T. F. were
                      supported by the Human Brain Project of the NIMH
                      (R01-MH074457-01A1).},
      abstract     = {Whether we feel sympathy for another, listen to our
                      heartbeat, experience pain or negotiate, the insular cortex
                      is thought to integrate perceptions, emotions, thoughts, and
                      plans into one subjective image of "our world". The insula
                      has hence been ascribed an integrative role, linking
                      information from diverse functional systems. Nevertheless,
                      various anatomical and functional studies in humans and
                      non-human primates also indicate a functional
                      differentiation of this region. In order to investigate this
                      functional differentiation as well as the mechanisms of the
                      functional integration in the insula, we performed
                      activation-likelihood-estimation (ALE) meta-analyses of
                      1,768 functional neuroimaging experiments. The analysis
                      revealed four functionally distinct regions on the human
                      insula, which map to the social-emotional, the sensorimotor,
                      the olfacto-gustatory, and the cognitive network of the
                      brain. Sensorimotor tasks activated the mid-posterior and
                      social-emotional tasks the anterior-ventral insula. In the
                      central insula activation by olfacto-gustatory stimuli was
                      found, and cognitive tasks elicited activation in the
                      anterior-dorsal region. A conjunction analysis across these
                      domains revealed that aside from basic somatosensory and
                      motor processes all tested functions overlapped on the
                      anterior-dorsal insula. This overlap might constitute a
                      correlate for a functional integration between different
                      functional systems and thus reflect a link between them
                      necessary to integrate different qualities into a coherent
                      experience of the world and setting the context for thoughts
                      and actions.},
      keywords     = {Afferent Pathways: anatomy $\&$ histology / Afferent
                      Pathways: physiology / Brain Mapping: methods / Cerebral
                      Cortex: anatomy $\&$ histology / Cerebral Cortex: physiology
                      / Cognition: physiology / Emotions: physiology / Humans /
                      Models, Neurological / Neural Pathways: anatomy $\&$
                      histology / Neural Pathways: physiology / Psychomotor
                      Performance: physiology / Self Concept / Smell: physiology /
                      Social Behavior / Taste: physiology / J (WoSType)},
      cin          = {INM-2 / JARA-BRAIN},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-2-20090406 / $I:(DE-82)080010_20140620$},
      pnm          = {Funktion und Dysfunktion des Nervensystems (FUEK409) /
                      89571 - Connectivity and Activity (POF2-89571)},
      pid          = {G:(DE-Juel1)FUEK409 / G:(DE-HGF)POF2-89571},
      shelfmark    = {Anatomy $\&$ Morphology / Neurosciences},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:20512376},
      UT           = {WOS:000278898300010},
      doi          = {10.1007/s00429-010-0255-z},
      url          = {https://juser.fz-juelich.de/record/10220},
}