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@ARTICLE{Becker:10221,
      author       = {Becker, J. S. and Niehren, S. and Matusch, A. and Wu, B.
                      and Hsieh, H.F. and Kumtabtim, U. and Hamester, M. and
                      Plaschke-Schlütter, A. and Salber, D.},
      title        = {{S}caling down the bioimaging of metals by laser
                      microdissection inductively coupled plasma mass spectrometry
                      ({LMD}-{ICP}-{MS})},
      journal      = {International journal of mass spectrometry},
      volume       = {294},
      issn         = {1387-3806},
      address      = {[S.l.]},
      publisher    = {Elsevier Science},
      reportid     = {PreJuSER-10221},
      pages        = {1 - 6},
      year         = {2010},
      note         = {The authors would like to thank A. Zimmermann
                      (Forschungszentrum Julich) for technical assistance during
                      the LMD-ICP-MS measurements. Bei Wu thanks the Alexander von
                      Humboldt foundation for financially supporting her
                      postdoctoral studies on nano-LA-ICP-MS.},
      abstract     = {Laser ablation inductively coupled plasma mass spectrometry
                      (LA-ICP-MS) has been established as a powerful quantitative
                      elemental imaging technique in routine mode for biological
                      tissue with a spatial resolution of 12-160 mu m. Several
                      applications necessitate an improved spatial resolution of
                      LA-ICP-MS at the low micrometre scale and below. To achieve
                      the improvement of spatial resolution of LA-ICP-MS we
                      created a new experimental arrangement by coupling a laser
                      microdissection system (LMD) used for laser ablation of
                      tissue with a sensitive quadrupole-based inductively coupled
                      plasma mass spectrometer for the subsequent analysis of
                      ablated material. A flat laser ablation chamber made of
                      glass was inserted into the LMD, fitted to the microscope
                      slide with the specimen. The biological tissue fixed on the
                      glass slide was ablated using the focused solid-state Nd:YAG
                      laser of the LMD. The laser ablated material was transported
                      by argon as carrier gas into the inductively coupled plasma
                      of the mass spectrometer and analysed according to the
                      mass-to-charge ratio. Using this novel LMD-ICP-MS
                      arrangement, in initial experiments ion signals of 63Cu* and
                      65Cte were measured from a 30-p.m-thick cryosection
                      impregnated with a droplet of a Cu solution. A spatial
                      resolution of about 3 pm was obtained using the modified LMD
                      system coupled to the ICP-MS. Laser-induced mass
                      spectrometric measurements of metal distributions can be
                      performed together with simultaneous inspection of the
                      tissue section via the microscope of the LMD and be combined
                      with other modalities of the LMD system. In future, a more
                      powerful laser in the LMD apparatus will allow ablation down
                      to the sub-micrometre scale to study the elemental
                      distribution in small tissue sections. (C) 2010 Elsevier By.
                      All rights reserved.},
      keywords     = {J (WoSType)},
      cin          = {INM-2 / ZCH / INM-4},
      ddc          = {530},
      cid          = {I:(DE-Juel1)INM-2-20090406 / I:(DE-Juel1)ZCH-20090406 /
                      I:(DE-Juel1)INM-4-20090406},
      pnm          = {Funktion und Dysfunktion des Nervensystems (FUEK409) /
                      89573 - Neuroimaging (POF2-89573)},
      pid          = {G:(DE-Juel1)FUEK409 / G:(DE-HGF)POF2-89573},
      shelfmark    = {Physics, Atomic, Molecular $\&$ Chemical / Spectroscopy},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000279462700001},
      doi          = {10.1016/j.ijms.2010.03.013},
      url          = {https://juser.fz-juelich.de/record/10221},
}