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@ARTICLE{Haaf:1022121,
      author       = {Haaf, Raoul and Brandi, Marie-Luise and Albantakis, Laura
                      and Lahnakoski, Juha M. and Henco, Lara and Schilbach,
                      Leonhard},
      title        = {{P}eripheral oxytocin levels are linked to hypothalamic
                      gray matter volume in autistic adults: a cross-sectional
                      secondary data analysis},
      journal      = {Scientific reports},
      volume       = {14},
      number       = {1},
      issn         = {2045-2322},
      address      = {[London]},
      publisher    = {Macmillan Publishers Limited, part of Springer Nature},
      reportid     = {FZJ-2024-01242},
      pages        = {1380},
      year         = {2024},
      abstract     = {Oxytocin (OXT) is known to modulate social behavior and
                      cognition and has been discussed as pathophysiological and
                      therapeutic factor for autism spectrum disorder (ASD). An
                      accumulating body of evidence indicates the hypothalamus to
                      be of particular importance with regard to the underlying
                      neurobiology. Here we used a region of interest voxel-based
                      morphometry (VBM) approach to investigate hypothalamic gray
                      matter volume (GMV) in autistic (n = 29, age
                      36.03 ± 11.0) and non-autistic adults (n = 27, age
                      30.96 ± 11.2). Peripheral plasma OXT levels and the
                      autism spectrum quotient (AQ) were used for correlation
                      analyses. Results showed no differences in hypothalamic GMV
                      in autistic compared to non-autistic adults but suggested a
                      differential association between hypothalamic GMV and OXT
                      levels, such that a positive association was found for the
                      ASD group. In addition, hypothalamic GMV showed a positive
                      association with autistic traits in the ASD group. Bearing
                      in mind the limitations such as a relatively small sample
                      size, a wide age range and a high rate of
                      psychopharmacological treatment in the ASD sample, these
                      results provide new preliminary evidence for a potentially
                      important role of the HTH in ASD and its relationship to the
                      OXT system, but also point towards the importance of
                      interindividual differences.},
      cin          = {INM-7},
      ddc          = {600},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5252},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {38228703},
      UT           = {WOS:001146669200039},
      doi          = {10.1038/s41598-023-50770-5},
      url          = {https://juser.fz-juelich.de/record/1022121},
}