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@ARTICLE{Serio:1022128,
      author       = {Serio, Bianca and Hettwer, Meike D. and Wiersch, Lisa and
                      Bignardi, Giacomo and Sacher, Julia and Weis, Susanne and
                      Eickhoff, Simon B. and Valk, Sofie L.},
      title        = {{S}ex differences in intrinsic functional cortical
                      organization reflect differences in network topology rather
                      than cortical morphometry},
      reportid     = {FZJ-2024-01249},
      year         = {2023},
      note         = {We want to thank the Human Connectome Project, Washington
                      University, the University of Minnesota, and Oxford
                      University Consortium (Principal Investigators: David Van
                      Essen and Kamil Ugurbil; 1U54MH091657) originally funded by
                      the 16 N.I.H. Institutes and Centers that support the N.I.H.
                      Blueprint for Neuroscience Research; and by the McDonnell
                      Center for Systems Neuroscience at Washington University.
                      BS, MDH, and GB were funded by the German Federal Ministry
                      of Education and Research (BMBF) and the Max Planck Society.
                      JS was funded by the Max Planck Society and University of
                      Leipzig. LW, SW, and SBE was funded by the European
                      Union’s Horizon 2020 Research and Innovation Program
                      (grant agreements 945539 [HBP SGA3], 826421 [VBC], and
                      101058516), the DFG (SFB 1451 and IRTG 2150), and the
                      National Institute of Health (NIH; R01 MH074457). SLV was
                      supported by the Max Planck Society through the Otto Hahn
                      Award.},
      abstract     = {Brain size robustly differs between sexes. However, the
                      consequences of this anatomical dimorphism on sex
                      differences in intrinsic brain function remain unclear. We
                      investigated the extent to which sex differences in
                      intrinsic cortical functional organization may be explained
                      by differences in cortical morphometry, namely brain size,
                      microstructure, and the geodesic distances of connectivity
                      profiles. For this, we computed a low dimensional
                      representation of functional cortical organization, the
                      sensory-association axis, and identified widespread sex
                      differences. Contrary to our expectations, observed sex
                      differences in functional organization were not
                      fundamentally associated with differences in brain size,
                      microstructural organization, or geodesic distances, despite
                      these morphometric properties being per se associated with
                      functional organization and differing between sexes.
                      Instead, functional sex differences in the
                      sensory-association axis were associated with differences in
                      functional connectivity profiles and network topology.
                      Collectively, our findings suggest that sex differences in
                      functional cortical organization extend beyond sex
                      differences in cortical morphometry.},
      cin          = {INM-7},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525) / 5251 -
                      Multilevel Brain Organization and Variability (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5252 / G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)25},
      doi          = {10.1101/2023.11.23.568437},
      url          = {https://juser.fz-juelich.de/record/1022128},
}