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@ARTICLE{Saivish:1022187,
      author       = {Saivish, Marielena Vogel and Menezes, Gabriela de Lima and
                      da Silva, Roosevelt Alves and de Assis, Leticia Ribeiro and
                      Teixeira, Igor da Silva and Fulco, Umberto Laino and Avilla,
                      Clarita Maria Secco and Eberle, Raphael Josef and Santos,
                      Igor de Andrade and Korostov, Karolina and Webber, Mayara
                      Lucia and da Silva, Gislaine Celestino Dutra and Nogueira,
                      Maurício Lacerda and Jardim, Ana Carolina Gomes and
                      Regasin, Luis Octavio and Coronado, Mônika Aparecida and
                      Pacca, Carolina Colombelli},
      title        = {{A}cridones as promising drug candidates against
                      {O}ropouche virus},
      journal      = {Current research in microbial sciences},
      volume       = {6},
      issn         = {2666-5174},
      address      = {Amsterdam},
      publisher    = {Elsevier B.V.},
      reportid     = {FZJ-2024-01308},
      pages        = {100217 -},
      year         = {2024},
      abstract     = {Oropouche virus (OROV) is an emerging vector-borne
                      arbovirus found in South America that causes Oropouche
                      fever, a febrile infection similar to dengue fever. It has a
                      high epidemic potential, causing illness in over 500,000
                      cases diagnosed since the virus was first discovered in
                      1955. Currently, the prevention of human viral infection
                      depends on vaccination, but availability for many viruses is
                      limited, and they are classified as neglected viruses. At
                      present, there are no vaccines or antiviral treatments
                      available. An alternative approach to limiting the spread of
                      the virus is to selectively disrupt viral replication
                      mechanisms. Here, we demonstrate the inhibitory effect of
                      acridones, which efficiently inhibited viral replication by
                      99.9 $\%$ in vitro. To evaluate possible mechanisms of
                      action, we conducted tests with dsRNA, an intermediate in
                      virus replication, as well as MD simulations, docking, and
                      binding free energy analysis. The results showed a strong
                      interaction between FAC21 and the OROV endonuclease, which
                      possibly limits the interaction of viral RNA with other
                      proteins. Therefore, our results suggest a dual mechanism of
                      antiviral action, possibly caused by ds-RNA intercalation.
                      In summary, our findings demonstrate that a new generation
                      of antiviral drugs could be developed based on the selective
                      optimization of molecules.},
      cin          = {IBI-7},
      ddc          = {570},
      cid          = {I:(DE-Juel1)IBI-7-20200312},
      pnm          = {5241 - Molecular Information Processing in Cellular Systems
                      (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5241},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {38234431},
      UT           = {WOS:001152529700001},
      doi          = {10.1016/j.crmicr.2023.100217},
      url          = {https://juser.fz-juelich.de/record/1022187},
}