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@INPROCEEDINGS{Biehl:1022333,
      author       = {Biehl, Ralf},
      title        = {{P}rotein interactions with {PEG}},
      reportid     = {FZJ-2024-01450},
      year         = {2023},
      abstract     = {Protein-polymer interactions are a key point to understand
                      and improve the activity of proteins and polymer in many bio
                      related applications. Polyethylene glycol (PEG) is a widely
                      used bio compatible polymer with applications reaching from
                      antifouling, over crystallization helper to PEGylation of
                      therapeutic drugs. Neutron scattering is an ideal method to
                      examine protein PEG interactions because of the possibility
                      to match PEG to D2O.I present here examples how protein-PEG
                      systems can be examined by SANS/SAXS combined with neutron
                      spinecho spectroscopy (NSE) to determine interactions
                      between PEG and proteins on nanometer length scale and a
                      timescale up to hundred nanoseconds.Matched hd-PEG can be
                      used to examine the tracer diffusion of proteins in crowded
                      environment. Matched maleimide-PEG allows to examine domain
                      dynamics changes due to the bound maleimide-PEG. Combined
                      SAXS/SANS analysis allows to examine hydration water and PEG
                      protein interaction.},
      month         = {May},
      date          = {2023-05-22},
      organization  = {MLZ Conference 2023: Neutrons for
                       Biomaterials, München (Germany), 22
                       May 2023 - 25 May 2023},
      subtyp        = {Plenary/Keynote},
      cin          = {JCNS-1 / IBI-8},
      cid          = {I:(DE-Juel1)JCNS-1-20110106 / I:(DE-Juel1)IBI-8-20200312},
      pnm          = {6G4 - Jülich Centre for Neutron Research (JCNS) (FZJ)
                      (POF4-6G4) / 632 - Materials – Quantum, Complex and
                      Functional Materials (POF4-632) / 5251 - Multilevel Brain
                      Organization and Variability (POF4-525) / 5241 - Molecular
                      Information Processing in Cellular Systems (POF4-524)},
      pid          = {G:(DE-HGF)POF4-6G4 / G:(DE-HGF)POF4-632 /
                      G:(DE-HGF)POF4-5251 / G:(DE-HGF)POF4-5241},
      typ          = {PUB:(DE-HGF)6},
      url          = {https://juser.fz-juelich.de/record/1022333},
}