%0 Journal Article
%A Jiang, Lin
%A Eickhoff, Simon B.
%A Genon, Sarah
%A Wang, Guangying
%A Yi, Chanlin
%A He, Runyang
%A Huang, Xunan
%A Yao, Dezhong
%A Dong, Debo
%A Li, Fali
%A Xu, Peng
%T Multimodal Covariance Network Reflects Individual Cognitive Flexibility
%J International journal of neural systems
%V 34
%N 4
%@ 0129-0657
%C Singapore [u.a.]
%I World Scientific Publ. Co.
%M FZJ-2024-01698
%P 2450018
%D 2024
%X Cognitive flexibility refers to the capacity to shift between patterns of mental function and relies on functional activity supported by anatomical structures. However, how the brain's structural-functional covarying is preconfigured in the resting state to facilitate cognitive flexibility under tasks remains unrevealed. Herein, we investigated the potential relationship between individual cognitive flexibility performance during the trail-making test (TMT) and structural-functional covariation of the large-scale multimodal covariance network (MCN) using magnetic resonance imaging (MRI) and electroencephalograph (EEG) datasets of 182 healthy participants. Results show that cognitive flexibility correlated significantly with the intra-subnetwork covariation of the visual network (VN) and somatomotor network (SMN) of MCN. Meanwhile, inter-subnetwork interactions across SMN and VN/default mode network/frontoparietal network (FPN), as well as across VN and ventral attention network (VAN)/dorsal attention network (DAN) were also found to be closely related to individual cognitive flexibility. After using resting-state MCN connectivity as representative features to train a multi-layer perceptron prediction model, we achieved a reliable prediction of individual cognitive flexibility performance. Collectively, this work offers new perspectives on the structural-functional coordination of cognitive flexibility and also provides neurobiological markers to predict individual cognitive flexibility.Keywords: Cognitive flexibility; EEG-MRI; multimodal covariance network; response prediction; trail-making test.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ 38372035
%U <Go to ISI:>//WOS:001164162800001
%R 10.1142/S0129065724500187
%U https://juser.fz-juelich.de/record/1023459