%0 Journal Article
%A Wang, Yaping
%A Wang, Yufan
%A Wang, Haiyan
%A Ma, Liang
%A Eickhoff, Simon B.
%A Madsen, Kristoffer Hougaard
%A Chu, Congying
%A Fan, Lingzhong
%T Spatio-molecular profiles shape the human cerebellar hierarchy along the sensorimotor-association axis
%J Cell reports
%V 43
%N 2
%@ 2211-1247
%C [New York, NY]
%I Elsevier
%M FZJ-2024-01699
%P 113770 -
%D 2024
%X Cerebellar involvement in both motor and non-motor functions manifests in specific regions of the human cerebellum, revealing the functional heterogeneity within it. One compelling theory places the heterogeneity within the cerebellar functional hierarchy along the sensorimotor-association (SA) axis. Despite extensive neuroimaging studies, evidence for the cerebellar SA axis from different modalities and scales was lacking. Thus, we establish a significant link between the cerebellar SA axis and spatio-molecular profiles. Utilizing the gene set variation analysis, we find the intermediate biological principles the significant genes leveraged to scaffold the cerebellar SA axis. Interestingly, we find these spatio-molecular profiles notably associated with neuropsychiatric dysfunction and recent evolution. Furthermore, cerebello-cerebral interactions at genetic and functional connectivity levels mirror the cerebral cortex and cerebellum's SA axis. These findings can provide a deeper understanding of how the human cerebellar SA axis is shaped and its role in transitioning from sensorimotor to association functions.Keywords: CP: Neuroscience; brain evolution; functional hierarchy; gene expression; human cerebellum; neuropsychiatric disorder.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ 38363683
%U <Go to ISI:>//WOS:001188121400001
%R 10.1016/j.celrep.2024.113770
%U https://juser.fz-juelich.de/record/1023460